A facile synthesis of (+)/(−)-pentenomycin I and analogs, and their antimicrobial evaluation

Takaaki Kamishima, Masato Suzuki, Shigenobu Aoyagi, Toshihiro Watanabe, Yoshitaka Koseki, Hitoshi Kasai

    研究成果: Article査読

    1 被引用数 (Scopus)

    抄録

    This study reported a stereoselective synthesis of (+)/(+)-pentenomycin I in 4–5 steps through regioselective silylation, optical resolution and dihydroxylation, followed by an olefin formation, from a known racemic cyclopentenone prepared from 2-deoxy-D-glucose. We also accomplished the transformation of a common intermediate into a variety of analogs. In addition, the antimicrobial activities of the pentenomycin analogs were evaluated, which revealed important structural factors of pentenomycins for the antimicrobial activities.

    本文言語English
    ページ(範囲)1375-1378
    ページ数4
    ジャーナルTetrahedron Letters
    60
    20
    DOI
    出版ステータスPublished - 2019 5 16

    ASJC Scopus subject areas

    • 生化学
    • 創薬
    • 有機化学

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