A de novo CHD3 variant in a child with intellectual disability, autism, joint laxity, and dysmorphisms

Miyako Mizukami, Aki Ishikawa, Sachiko Miyazaki, Akiko Tsuzuki, Sakae Saito, Tetsuya Niihori, Akihiro Sakurai

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Background: Chromodomain helicase DNA-binding (CHD) proteins play important roles in developmental processes. CHD3, a member of the CHD family of proteins, was reported to be a cause of a neurodevelopmental syndrome by Snijders Blok et al., but only a small number of probands have been reported. Case report: The patient was a 9-year-old female with severe intellectual disability, speech impairment, autism, joint laxity and dysmorphisms. Whole exome sequencing revealed a de novo missense variant in CHD3 (NM_001005273:exon18: c.2896C > T:p.R966W). Conclusion: We report a case with a pathogenic variant in the CHD3 gene. Our report indicates that CHD3 analysis is helpful for diagnosis of the cases with neurodevelopmental disorders, joint laxity, and coarse facial phenotype.

本文言語English
ページ(範囲)563-565
ページ数3
ジャーナルBrain and Development
43
4
DOI
出版ステータスPublished - 2021 4

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 発達神経科学
  • 臨床神経学

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