A cyclopentanediol analogue selectively suppresses the conserved innate immunity pathways, Drosophila IMD and TNF-α pathways

Mizuki Sekiya, Kazunori Ueda, Kaori Okazaki, Haruhisa Kikuchi, Shoichiro Kurata, Yoshiteru Oshima

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Innate immunity comprises evolutionarily conserved self-defense mechanisms against microbial infections. In mammals, innate immunity interacts with adaptive immunity and has a key role in the regulated immune response. Therefore, innate immunity is a pharmaceutical target for the development of immune regulators. Using Drosophila ex vivo culture systems, we isolated a cyclopentanediol analogue from Aspergillus sp. as an immunosuppressive substance. This compound selectively suppressed activation of the IMD pathway in Drosophila in vivo and the target molecules of the compound lie between the Imd adaptor protein and dTAK1 kinase in the IMD pathway. In human cells, the compound suppressed TNF-α, but not IL-1β, stimulation-induced activation of NF-κB, suggesting that its target molecules are upstream of TAK1 in mammalian innate immunity.

本文言語English
ページ(範囲)2165-2174
ページ数10
ジャーナルBiochemical Pharmacology
75
11
DOI
出版ステータスPublished - 2008 6 1

ASJC Scopus subject areas

  • 生化学
  • 薬理学

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