A controlled-release capsule device for transscleral drug delivery to the retina

研究成果: Conference contribution

抄録

We report the design and testing of a transscleral drug delivery system that is implantable in the episclera and allows for controlled release of brain-derived neurotrophic factor (BDNF) or other protein-type drugs with zero-order kinetics. The microfabricated capsule consists of a drug reservoir sealed with a controlled-release membrane that contains interconnected collagen microparticles (COLs), which are the routes for drug permeation. The drug kinetics can be controlled by changing the drug formulation and/or the membrane COL density so that the size of the bursts is reduced, which extends the release period. When capsules were sutured onto sclerae of rabbit eyes, a drug mimic was found to spread to the retinal pigment epithelium. Implantation of the device was easy, and it did not damage the eye tissues.

本文言語English
ホスト出版物のタイトルProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
出版社Chemical and Biological Microsystems Society
ページ452-454
ページ数3
ISBN(印刷版)9780979806452
出版ステータスPublished - 2012 1 1
イベント16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
継続期間: 2012 10 282012 11 1

出版物シリーズ

名前Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
国/地域Japan
CityOkinawa
Period12/10/2812/11/1

ASJC Scopus subject areas

  • 化学工学(その他)
  • バイオエンジニアリング

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