A concise total synthesis of (-)-indolactam v

Toshiharu Noji, Kentaro Okano, Hidetoshi Tokuyama

研究成果: Article査読

26 被引用数 (Scopus)

抄録

One-pot synthesis of tryptophanol derivative from N-Boc-aziridine and indole has been developed. The ring opening reaction of the aziridine takes place smoothly at -30°C in a regioselective manner and tolerates a wide range of functional groups including halogens attached to the aromatic ring, which was also performed on a gram scale. The resulting tryptophanol derivative was converted to (-)-indolactam V from commercially available 4-bromoindole through a copper-mediated aryl amination in nine steps with an overall yield of 32%.

本文言語English
ページ(範囲)3833-3837
ページ数5
ジャーナルTetrahedron
71
23
DOI
出版ステータスPublished - 2015 5月 26

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

フィンガープリント

「A concise total synthesis of (-)-indolactam v」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル