A concise synthesis of pinellic acid using a cross-metathesis approach

Ayako Miura, Shigefumi Kuwahara

研究成果: Article査読

29 被引用数 (Scopus)

抄録

A new enantioselective synthesis of pinellic acid, a trihydroxy unsaturated fatty acid exhibiting oral adjuvant activity for nasally administered influenza vaccine, has been accomplished using a cross-metathesis reaction between two terminal olefin intermediates as the key step. This synthesis is the shortest to date, furnishing pinellic acid in 17% overall yield via only seven steps from a readily available known dihydroxy ester.

本文言語English
ページ(範囲)3364-3368
ページ数5
ジャーナルTetrahedron
65
17
DOI
出版ステータスPublished - 2009 4 25

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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