A Concise Enantioselective Synthesis of a Key A-Ring Synthon for 1α-Hydroxyvitamin D3 Compounds

Hiroko Hiyamizu, Hidenori Ooi, Yoko Inomoto, Tomoyuki Esumi, Yoshiharu Iwabuchi, Susumi Hatakeyama

研究成果: Article査読

15 被引用数 (Scopus)

抄録

(Matrix Presented) This report describes a concise enantioselective synthesis of the A-ring synthon for the synthesis of 1α-hydroxyvitamin D3 compounds. The synthesis involves two notable transformations: (i) stereoselective construction of the enol triflate from the vinyl ketone by Michael addition of Ph2P(O)Li followed by in situ triftation of the resulting enolate and (ii) palladium-catalyzed Heck type cyclization of the enol triflate.

本文言語English
ページ(範囲)473-475
ページ数3
ジャーナルOrganic letters
3
3
DOI
出版ステータスPublished - 2001 2 8
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

フィンガープリント 「A Concise Enantioselective Synthesis of a Key A-Ring Synthon for 1α-Hydroxyvitamin D<sub>3</sub> Compounds」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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