A Concise Enantioselective Synthesis of a Key A-Ring Synthon for 1α-Hydroxyvitamin D3 Compounds

Hiroko Hiyamizu; Hidenori Ooi; Yoko Inomoto; Tomoyuki Esumi; Yoshiharu Iwabuchi; Susumi Hatakeyama

doi:10.1021/ol006982u

A Concise Enantioselective Synthesis of a Key A-Ring Synthon for 1α-Hydroxyvitamin D₃ Compounds

Hiroko Hiyamizu, Hidenori Ooi, Yoko Inomoto, Tomoyuki Esumi, Yoshiharu Iwabuchi, Susumi Hatakeyama

研究成果: Article › 査読

15 被引用数 (Scopus)

抄録

(Matrix Presented) This report describes a concise enantioselective synthesis of the A-ring synthon for the synthesis of 1α-hydroxyvitamin D₃ compounds. The synthesis involves two notable transformations: (i) stereoselective construction of the enol triflate from the vinyl ketone by Michael addition of Ph₂P(O)Li followed by in situ triftation of the resulting enolate and (ii) palladium-catalyzed Heck type cyclization of the enol triflate.

本文言語	English
ページ（範囲）	473-475
ページ数	3
ジャーナル	Organic letters
巻	3
号	3
DOI	https://doi.org/10.1021/ol006982u
出版ステータス	Published - 2001 2 8
外部発表	はい

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

文献へのアクセス

10.1021/ol006982u

フィンガープリント「A Concise Enantioselective Synthesis of a Key A-Ring Synthon for 1α-Hydroxyvitamin D<sub>3</sub> Compounds」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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AU - Esumi, Tomoyuki

AU - Iwabuchi, Yoshiharu

AU - Hatakeyama, Susumi

PY - 2001/2/8

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