A computational study on the possibility of the initialization and development of intracranial aneurysms considering biofluid and biosolid mechanics

Yixiang Feng, Shigeo Wada, Takami Yamaguchi

研究成果: Chapter

抄録

Intracranial aneurysms are local dilations of the arterial wall which have a very high morbidity rate if they rupture. Although the mechanism initiation, growth, and rupture of intracranial aneurysms are still unknown yet, it is believed to be closely related to both biosolid and biofluid mechanics. Therefore, a multi-physical model is needed to study the pathophysiology of intracranial aneurysms. In this study, we introduce a numerical model on the development of intracranial aneurysms considering the interaction between fluid and structure interaction. The blood flow is considered to be incompressible, Newtonian, and laminar. The vessel wall is considered to be elastic and isotropic. The coupling between the structural and fluid domain is performed using a two-way weak coupling method. Three general shapes are adopted in this study, namely a straight vessel, a curved vessel, and a vessel with bifurcations. They represent vessel geometries that are most typical to the cerebral vasculature. The numerical model is a "rule-base" one in a sense that different kinds of rules can be tested. In our study, we adopt the high wall shear stress hypothesis as a cause for aneurysm initiation and development. A threshold value is used for the wall shear stress. It is shown that aneurysm initiation and development can be realized using our numerical model. And the influence of WSS threshold, the Reynolds number and some other parameters are also discussed.

本文言語English
ホスト出版物のタイトルSingle and Two-Phase Flows on Chemical and Biomedical Engineering
出版社Bentham Science Publishers Ltd.
ページ613-633
ページ数21
ISBN(印刷版)9781608053476
DOI
出版ステータスPublished - 2012

ASJC Scopus subject areas

  • Engineering(all)

フィンガープリント 「A computational study on the possibility of the initialization and development of intracranial aneurysms considering biofluid and biosolid mechanics」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル