A composite of hydroxyapatite with electrospun biodegradable nanofibers as a tissue engineering material

Yoshihiro Ito, Hirokazu Hasuda, Masanobu Kamitakahara, Chikara Ohtsuki, Masao Tanihara, Inn Kyu Kang, Oh Hyeong Kwon

研究成果: Article査読

227 被引用数 (Scopus)

抄録

Biodegradable and biocompatible poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV), a copolymer of microbial polyester, was fabricated as a nanofibrous film by electrospinning and composited with hydroxyapatite (HAp) by soaking in simulated body fluid. Compared with a PHBV cast (flat) film, the electrospun PHBV nanofibrous film was hydrophobic. However, after HAp deposition, both of the surfaces were extremely hydrophilic. The degradation rate of HAp/PHBV nanofibrous films in the presence of polyhydroxybutyrate depolymerase was very fast. Nanofiber formation increased the specific surface area and HAp enhanced the invasion of enzyme into the film by increasing surface hydrophilicity. The surface of the nanofibrous film showed enhanced cell adhesion over that of the flat film, although cell adhesion was not significantly affected by the combination with HAp.

本文言語English
ページ(範囲)43-49
ページ数7
ジャーナルJournal of Bioscience and Bioengineering
100
1
DOI
出版ステータスPublished - 2005
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • バイオエンジニアリング
  • 応用微生物学とバイオテクノロジー

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