A comparative study of cefoselis and ceftazidime in chronic respiratory tract infections

Rinzo Soejima; Yoshihito Niki; Osamu Moriya; Masamitsu Nakajima; Kenjiro Kikuchi; Yoshinobu Osaki; Hitoshi Nakano; Jun Ichi Maruyama; Hideaki Omiya; Tetsuo Shimizu; Hirotaka Hashizume; Yuka Fujita; Yutaka Nishigaki; Tadakatsu Tsuji; Satoru Tanasawa; Satoshi Koyama; Akira Saito; Kazuo Takebe; Yuichi Hirai; Kazuki Konishi; Hiroshi Inoue; Kenichi Takeuchi; Masashi Tamura; Toshihiro Nukiwa; Akira Watanabe; Yushi Nakai; Yoshihiro Honda; Shigeo Takizawa; Kenji Yanagise; Mikae Nakamura; Shoko Tagami; Kohya Shiba; Osamu Sakai; Kazuhisa Okada; Kaoru Shimada; Yasuyuki Sano; Yasuo Arai; Hiroyuki Kobayashi; Susumu Sakayori; Hiroshi Miura; Kihachiro Shimizu; Yukio Suzuki; Fumio Matsumoto; Takeo Imai; Shigeki Odagiri; Kaneo Suzuki; Hiroshi Takahashi; Kenichi Takahashi; Yasuhiro Yoshiike; Takashi Ogura; Yoshihiro Hirai; Tadashi Akahori; Hidekazu Kitamura; Yuriko Ishimaru; Satoshi Inoue; Takao Okubo; Hirotada Ikeda; Hiroshi Matsumoto; Shoichiro Irimajiri; Yasuo Matsuoka; Yasuo Osone; Masaaki Arakawa; Kohichi Wada; Shigeyuki Hoshino; Akira Iwashima; Fumihide Iwata; Hiroyuki Sega; Samu Sekine; Yasutoshi Suzuki; Nobuki Aoki; Atsuro Honda; Toshihiko Hasizume; Atsuhiko Sato; Kingo Chida; Shiro Imokawa; Masatoshi Iwata; Rinko Kita; Masaaki Ida; Yutaka Nakano; Takayoshi Watanabe; Toshihiko Takeuchi; Yasuo Yamada; Atsushi Nakamura; Hidekazu Hanaki; Makoto Kawakami; Shinji Takeyama; Yuji Usami; Hideaki Kuroki; Tomoyuki Tashiro; Ryuji Nomura; Fumio Miki; Eiro Tsubura; Tomio Masuno; Masaru Nakagawa; Toshihiko Yamaguchi; Yoshihiro Takishita; Hiroyasu Bando; Yoshihiro Suzuki; Nobuhiro Narita

A comparative study of cefoselis and ceftazidime in chronic respiratory tract infections

Rinzo Soejima, Yoshihito Niki, Osamu Moriya, Masamitsu Nakajima, Kenjiro Kikuchi, Yoshinobu Osaki, Hitoshi Nakano, Jun Ichi Maruyama, Hideaki Omiya, Tetsuo Shimizu, Hirotaka Hashizume, Yuka Fujita, Yutaka Nishigaki, Tadakatsu Tsuji, Satoru Tanasawa, Satoshi Koyama, Akira Saito, Kazuo Takebe, Yuichi Hirai, Kazuki KonishiHiroshi Inoue, Kenichi Takeuchi, Masashi Tamura, Toshihiro Nukiwa, Akira Watanabe, Yushi Nakai, Yoshihiro Honda, Shigeo Takizawa, Kenji Yanagise, Mikae Nakamura, Shoko Tagami, Kohya Shiba, Osamu Sakai, Kazuhisa Okada, Kaoru Shimada, Yasuyuki Sano, Yasuo Arai, Hiroyuki Kobayashi, Susumu Sakayori, Hiroshi Miura, Kihachiro Shimizu, Yukio Suzuki, Fumio Matsumoto, Takeo Imai, Shigeki Odagiri, Kaneo Suzuki, Hiroshi Takahashi, Kenichi Takahashi, Yasuhiro Yoshiike, Takashi Ogura, Yoshihiro Hirai, Tadashi Akahori, Hidekazu Kitamura, Yuriko Ishimaru, Satoshi Inoue, Takao Okubo, Hirotada Ikeda, Hiroshi Matsumoto, Shoichiro Irimajiri, Yasuo Matsuoka, Yasuo Osone, Masaaki Arakawa, Kohichi Wada, Shigeyuki Hoshino, Akira Iwashima, Fumihide Iwata, Hiroyuki Sega, Samu Sekine, Yasutoshi Suzuki, Nobuki Aoki, Atsuro Honda, Toshihiko Hasizume, Atsuhiko Sato, Kingo Chida, Shiro Imokawa, Masatoshi Iwata, Rinko Kita, Masaaki Ida, Yutaka Nakano, Takayoshi Watanabe, Toshihiko Takeuchi, Yasuo Yamada, Atsushi Nakamura, Hidekazu Hanaki, Makoto Kawakami, Shinji Takeyama, Yuji Usami, Hideaki Kuroki, Tomoyuki Tashiro, Ryuji Nomura, Fumio Miki, Eiro Tsubura, Tomio Masuno, Masaru Nakagawa, Toshihiko Yamaguchi, Yoshihiro Takishita, Hiroyasu Bando, Yoshihiro Suzuki, Nobuhiro Narita

研究成果: Article › 査読

抄録

The clinical efficacy, safety and usefulness of cefoselis (FK 037, CFSL), a new parenteral cephalosporin, were evaluated in chronic respiratory tract infection in a comparative study with ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days. The following results were obtained. 1. A total of 167 patients were enrolled in this study. Efficacy rates ('good' and better responses) were 90.3% (65/72) in the CFSL group and 89.7% (61/68) in the CAZ group. 2. Bacteriological effects (eradication rates) were 89.2% (33/37) in the CFSL group and 94.1% (32/34) in the CAZ group. 3. Adverse reactions occurred in 6 of the 81 patients in the CFSL group and in 2 of the 76 patients in the CAZ group. The incidence of abnormal laboratory findings was 11.1% (9/81) in the CFSL group and 13.3% (10/75) in the CAZ group. 4. Usefulness rates ('useful' and better responses) were 84.9% (62/73) in the CFSL group and 86.8% (59/68) in the CAZ group. No significant difference was observed between the two groups in any of the above items. The results indicate that cefoselis is a useful drug in the treatment of chronic respiratory tract infections. This paper reports clinical results excluding cases violating Good Clinical Practice (GCP) found after publication of our previous paper in 'Jpn. J. Chemother.' (Vol. 43, No. 4, 1995).

本文言語	English
ページ（範囲）	527-544
ページ数	18
ジャーナル	Japanese Journal of Chemotherapy
巻	44
号	7
出版ステータス	Published - 1996 7月
外部発表	はい

ASJC Scopus subject areas

薬理学
薬理学（医学）

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引用スタイル

Soejima, R., Niki, Y., Moriya, O., Nakajima, M., Kikuchi, K., Osaki, Y., Nakano, H., Maruyama, J. I., Omiya, H., Shimizu, T., Hashizume, H., Fujita, Y., Nishigaki, Y., Tsuji, T., Tanasawa, S., Koyama, S., Saito, A., Takebe, K., Hirai, Y., ... Narita, N. (1996). A comparative study of cefoselis and ceftazidime in chronic respiratory tract infections. Japanese Journal of Chemotherapy, 44(7), 527-544.

Soejima, R, Niki, Y, Moriya, O, Nakajima, M, Kikuchi, K, Osaki, Y, Nakano, H, Maruyama, JI, Omiya, H, Shimizu, T, Hashizume, H, Fujita, Y, Nishigaki, Y, Tsuji, T, Tanasawa, S, Koyama, S, Saito, A, Takebe, K, Hirai, Y, Konishi, K, Inoue, H, Takeuchi, K, Tamura, M, Nukiwa, T, Watanabe, A, Nakai, Y, Honda, Y, Takizawa, S, Yanagise, K, Nakamura, M, Tagami, S, Shiba, K, Sakai, O, Okada, K, Shimada, K, Sano, Y, Arai, Y, Kobayashi, H, Sakayori, S, Miura, H, Shimizu, K, Suzuki, Y, Matsumoto, F, Imai, T, Odagiri, S, Suzuki, K, Takahashi, H, Takahashi, K, Yoshiike, Y, Ogura, T, Hirai, Y, Akahori, T, Kitamura, H, Ishimaru, Y, Inoue, S, Okubo, T, Ikeda, H, Matsumoto, H, Irimajiri, S, Matsuoka, Y, Osone, Y, Arakawa, M, Wada, K, Hoshino, S, Iwashima, A, Iwata, F, Sega, H, Sekine, S, Suzuki, Y, Aoki, N, Honda, A, Hasizume, T, Sato, A, Chida, K, Imokawa, S, Iwata, M, Kita, R, Ida, M, Nakano, Y, Watanabe, T, Takeuchi, T, Yamada, Y, Nakamura, A, Hanaki, H, Kawakami, M, Takeyama, S, Usami, Y, Kuroki, H, Tashiro, T, Nomura, R, Miki, F, Tsubura, E, Masuno, T, Nakagawa, M, Yamaguchi, T, Takishita, Y, Bando, H, Suzuki, Y & Narita, N 1996, 'A comparative study of cefoselis and ceftazidime in chronic respiratory tract infections', Japanese Journal of Chemotherapy, vol. 44, no. 7, pp. 527-544.

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T1 - A comparative study of cefoselis and ceftazidime in chronic respiratory tract infections

AU - Soejima, Rinzo

AU - Niki, Yoshihito

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AU - Kikuchi, Kenjiro

AU - Osaki, Yoshinobu

AU - Nakano, Hitoshi

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AU - Koyama, Satoshi

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AU - Takebe, Kazuo

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AU - Takeuchi, Kenichi

AU - Tamura, Masashi

AU - Nukiwa, Toshihiro

AU - Watanabe, Akira

AU - Nakai, Yushi

AU - Honda, Yoshihiro

AU - Takizawa, Shigeo

AU - Yanagise, Kenji

AU - Nakamura, Mikae

AU - Tagami, Shoko

AU - Shiba, Kohya

AU - Sakai, Osamu

AU - Okada, Kazuhisa

AU - Shimada, Kaoru

AU - Sano, Yasuyuki

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AU - Kobayashi, Hiroyuki

AU - Sakayori, Susumu

AU - Miura, Hiroshi

AU - Shimizu, Kihachiro

AU - Suzuki, Yukio

AU - Matsumoto, Fumio

AU - Imai, Takeo

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AU - Suzuki, Kaneo

AU - Takahashi, Hiroshi

AU - Takahashi, Kenichi

AU - Yoshiike, Yasuhiro

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AU - Hirai, Yoshihiro

AU - Akahori, Tadashi

AU - Kitamura, Hidekazu

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AU - Wada, Kohichi

AU - Hoshino, Shigeyuki

AU - Iwashima, Akira

AU - Iwata, Fumihide

AU - Sega, Hiroyuki

AU - Sekine, Samu

AU - Suzuki, Yasutoshi

AU - Aoki, Nobuki

AU - Honda, Atsuro

AU - Hasizume, Toshihiko

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AU - Chida, Kingo

AU - Imokawa, Shiro

AU - Iwata, Masatoshi

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AU - Ida, Masaaki

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AU - Watanabe, Takayoshi

AU - Takeuchi, Toshihiko

AU - Yamada, Yasuo

AU - Nakamura, Atsushi

AU - Hanaki, Hidekazu

AU - Kawakami, Makoto

AU - Takeyama, Shinji

AU - Usami, Yuji

AU - Kuroki, Hideaki

AU - Tashiro, Tomoyuki

AU - Nomura, Ryuji

AU - Miki, Fumio

AU - Tsubura, Eiro

AU - Masuno, Tomio

AU - Nakagawa, Masaru

AU - Yamaguchi, Toshihiko

AU - Takishita, Yoshihiro

AU - Bando, Hiroyasu

AU - Suzuki, Yoshihiro

AU - Narita, Nobuhiro

PY - 1996/7

Y1 - 1996/7

N2 - The clinical efficacy, safety and usefulness of cefoselis (FK 037, CFSL), a new parenteral cephalosporin, were evaluated in chronic respiratory tract infection in a comparative study with ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days. The following results were obtained. 1. A total of 167 patients were enrolled in this study. Efficacy rates ('good' and better responses) were 90.3% (65/72) in the CFSL group and 89.7% (61/68) in the CAZ group. 2. Bacteriological effects (eradication rates) were 89.2% (33/37) in the CFSL group and 94.1% (32/34) in the CAZ group. 3. Adverse reactions occurred in 6 of the 81 patients in the CFSL group and in 2 of the 76 patients in the CAZ group. The incidence of abnormal laboratory findings was 11.1% (9/81) in the CFSL group and 13.3% (10/75) in the CAZ group. 4. Usefulness rates ('useful' and better responses) were 84.9% (62/73) in the CFSL group and 86.8% (59/68) in the CAZ group. No significant difference was observed between the two groups in any of the above items. The results indicate that cefoselis is a useful drug in the treatment of chronic respiratory tract infections. This paper reports clinical results excluding cases violating Good Clinical Practice (GCP) found after publication of our previous paper in 'Jpn. J. Chemother.' (Vol. 43, No. 4, 1995).

AB - The clinical efficacy, safety and usefulness of cefoselis (FK 037, CFSL), a new parenteral cephalosporin, were evaluated in chronic respiratory tract infection in a comparative study with ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days. The following results were obtained. 1. A total of 167 patients were enrolled in this study. Efficacy rates ('good' and better responses) were 90.3% (65/72) in the CFSL group and 89.7% (61/68) in the CAZ group. 2. Bacteriological effects (eradication rates) were 89.2% (33/37) in the CFSL group and 94.1% (32/34) in the CAZ group. 3. Adverse reactions occurred in 6 of the 81 patients in the CFSL group and in 2 of the 76 patients in the CAZ group. The incidence of abnormal laboratory findings was 11.1% (9/81) in the CFSL group and 13.3% (10/75) in the CAZ group. 4. Usefulness rates ('useful' and better responses) were 84.9% (62/73) in the CFSL group and 86.8% (59/68) in the CAZ group. No significant difference was observed between the two groups in any of the above items. The results indicate that cefoselis is a useful drug in the treatment of chronic respiratory tract infections. This paper reports clinical results excluding cases violating Good Clinical Practice (GCP) found after publication of our previous paper in 'Jpn. J. Chemother.' (Vol. 43, No. 4, 1995).

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A comparative study of cefoselis and ceftazidime in chronic respiratory tract infections

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ASJC Scopus subject areas

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