A Circadian Variation in the Excretion of Urinary Kinin, Kallikrein and Prostaglandin E in Normal Volunteers

Keishi Abe, Makito Sato, Yutaka Kasai, Toshiaki Haruyama, Ko Sato, Seiji Miyazaki, Yutaka Imai, Masao Hiwatari, Toru Itoh, Yutaka Sakurai, Toshikazu Goto, Jiro Tajima, Masahide Seino, Kaoru Yoshinaga

研究成果: Article査読

9 被引用数 (Scopus)

抄録

The present study shows that there is a circadian variation in the excretion of urinary kinin, kallikrein and prostaglandin E (PGE) as well as urine flow, urinary sodium excretion and urinary potassium excretion in recumbent healthy volunteers. The present data, that the acrophase of urinary kallikrein excretion was 1.5 hr later than that of plasma aldosterone concentration (PAC) and that a significant positive correlation was found in circadian variations between urinary kallikrein and PAC, suggest that the circadian variation of urinary kallikrein excretion may be regulated by aldosterone. The pattern of circadian variation of average urinary kinin excretion coincided with those of average urine flow, urinary sodium excretion and urinary PGE excretion, suggesting that renal kinin and PGE may be involved in the regulation of water-sodium excretion. The present data that the phase of circadian variation of urinary kinin was delayed from that of urinary kallikrein and that there was a mirror image between the circadian variation in urinary kinin and kallikrein suggest that there may be a feedback mechanism in renal kallikrein-kinin system.

本文言語English
ページ(範囲)1098-1103
ページ数6
ジャーナルJAPANESE CIRCULATION JOURNAL
45
9
DOI
出版ステータスPublished - 1981

ASJC Scopus subject areas

  • 生理学
  • 循環器および心血管医学

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