A causal account of the brain network computations underlying strategic social behavior

Christopher A. Hill, Shinsuke Suzuki, Rafael Polania, Marius Moisa, John P. O'doherty, Christian C. Ruff

研究成果: Article査読

66 被引用数 (Scopus)

抄録

During competitive interactions, humans have to estimate the impact of their own actions on their opponent's strategy. Here we provide evidence that neural computations in the right temporoparietal junction (rTPJ) and interconnected structures are causally involved in this process. By combining inhibitory continuous theta-burst transcranial magnetic stimulation with model-based functional MRI, we show that disrupting neural excitability in the rTPJ reduces behavioral and neural indices of mentalizing-related computations, as well as functional connectivity of the rTPJ with ventral and dorsal parts of the medial prefrontal cortex. These results provide a causal demonstration that neural computations instantiated in the rTPJ are neurobiological prerequisites for the ability to integrate opponent beliefs into strategic choice, through system-level interaction within the valuation and mentalizing networks.

本文言語English
ページ(範囲)1142-1149
ページ数8
ジャーナルNature Neuroscience
20
8
DOI
出版ステータスPublished - 2017 8 1

ASJC Scopus subject areas

  • 神経科学(全般)

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