A case with anti-galactocerebroside antibody-positive Mycoplasma pneumoniae meningoencephalitis presenting secondary hypersomnia

Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasmaassociated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient's daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barré syndrome mediated by antiglycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.

本文言語English
ページ(範囲)1473-1476
ページ数4
ジャーナルNeurological Sciences
33
6
DOI
出版ステータスPublished - 2012 3 23

ASJC Scopus subject areas

  • 皮膚病学
  • 臨床神経学
  • 精神医学および精神衛生

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