A Case of Peritoneal Metastasis Resection from GIST of the Small Intestine with Focal Resistance Against Imatinib Mesylate

Tasuku Ono, Naoki Tanaka, Hideyuki Suzuki, Hirofumi Imoto, Akihiro Yamamura, Hideaki Karasawa, Atsushi Kohyama, Takeshi Aoki, Kazuhiro Watanabe, Shinobu Ohnuma, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naito, Michiaki Unno

研究成果: Article査読

抄録

A 69-year-old man was referred to our institute for the surgical resection of focal resistant peritoneal GIST during imatinib administration. He had been diagnosed with GIST of the small intestine with liver and peritoneal metastases, and imatinib treatment was initiated. Shortly after imatinib administration, the primary lesion perforated, and thus, partial resection of the small intestine was performed. Imatinib treatment was resumed after the first surgery, and he achieved partial response. However, computed tomography scans obtained 7 months after the first surgery showed focal progression, a peritoneal metastasis near the right kidney. Under the diagnosis of focally imatinib-resistant GIST, local resection of the metastatic tumor was performed. In this case, an exon 11 mutation of c-kit was noted initially. After the imatinib treatment, an additional point mutation was observed in exon 18 that caused resistance to imatinib. Therefore, imatinib treatment was reinitiated after the second surgery, and other metastases were well controlled. In case of GIST with multiple metastases, appropriate treatment should be selected based on the resistance of each lesion.

本文言語English
ページ(範囲)2452-2454
ページ数3
ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
46
13
出版ステータスPublished - 2019 12 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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