A case of curatively resected rectal cancer with preservation of urinary function after chemotherapy

Yasushi Mochizuki, Hideaki Karasawa, Norikazu Une, Shinobu Ohnuma, Hideyuki Suzuki, Hirofumi Imoto, Akihiro Yamamura, Atsushi Kohyama, Takeshi Aoki, Kazuhiro Watanabe, Naoki Tanaka, Hiroaki Musha, Takashi Kamei, Takeshi Naito, Michiaki Unno

研究成果: Review article査読


A 55-year-old man was diagnosed with rectal cancer invading the urinary bladder and swollen para-aortic lymph nodes. Since distant metastasis was indicated and total pelvic exenteration was required, 6 courses of chemotherapy with mFOLFOX6 plus panitumumab were performed. After the chemotherapy, the rectal cancer and para-aortic lymph nodes significantly decreased in size, and novel distant metastasis was not observed in CT scans. Therefore, the tumor was considered resectable, and operation was performed. Intraoperative frozen section analysis showed that the para-aortic lymph nodes and surgical margin of the urinary bladder were negative. Thus, low anterior resection of the rectum and partial resection of the urinary bladder were performed. RO resection was pathologically achieved, and adjuvant chemotherapy with S-1 was administered for 6 months. The patient is alive without recurrence for 10 months. Upfront chemotherapy can be a strategy for advanced rectal cancer with urinary bladder invasion to avoid total pelvic exenteration.

ジャーナルJapanese Journal of Cancer and Chemotherapy
出版ステータスPublished - 2019 4月

ASJC Scopus subject areas

  • 医学(全般)


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