6,11-Dideoxytetrodotoxin from the puffer fish, Fugu pardalis

研究成果: Article査読

38 被引用数 (Scopus)

抄録

The presence of an unknown dideoxy analog of tetrodotoxin was suggested on the liquid chromatography/electrospray ionization-mass spectrometry mass chromatogram of the ovaries of the puffer fish, Fugu pardalis, in single ion monitoring mode to detect at m/z 288. We succeeded to isolate this analog (approximately 0.4 mg) from 200 g of the ovaries and the structure was determined as 6,11-dideoxytetrodotoxin by spectroscopic methods (high resolution-fast atom bombardment-MS and NMR spectroscopy). The discovery of the new analog is highly significant with respect to the biosynthesis or metabolism of tetrodotoxin. We also roughly determined the value of IC50 (mice, intraperitoneal) for 6,11-dideoxytetrodotoxin as 420 μg/kg and thus it is 42 times less toxic than tetrodotoxin.

本文言語English
ページ(範囲)947-951
ページ数5
ジャーナルToxicon
50
7
DOI
出版ステータスPublished - 2007 12 1

ASJC Scopus subject areas

  • 毒物学

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