42. A Novel Point Mutation of the RET Proto-oncogene in Small Cell Lung Carcinoma Cell Lines

Hitoyasu Futami, Shin ichi Egawa, Ken Yamaguchi

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Point mutations of the RET proto-oncogene are associated with the development of inherited diseases including multiple endocrine neoplasia (MEN) type 2, familial medullary thyroid carcinoma (MTC), and Hirschsprung’s disease as well as a part of sporadic MTCs and pheochromocytomas. In the present study, we examined point mutations of the RET proto-oncogene in exons 10, 11 and 16 in small cell lung carcinoma (SCLC) cell lines. A novel point mutation from GCC to GAC at codon 664 in exon 11 was identified in 2 out of 6 SCLC cell lines; this alteration results in an amino acid substitution of aspartic acid for alanine. This point mutation was not detected in other types of cancer cell lines so far examined. Point mutations of the RET proto-oncogene reported previously in exons 10, 11 and 16 in above-mentioned diseases were not detected in the SCLC cell lines. These results suggest that this point mutation of the RET proto-oncogene is closely associated with a part of SCLC.

本文言語English
ページ(範囲)210-214
ページ数5
ジャーナルProceedings of the Japan Academy, Series B
70
10
DOI
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 農業および生物科学(全般)
  • 物理学および天文学(全般)

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