3D electrochemical and ion current imaging using scanning electrochemical-scanning ion conductance microscopy

Yasufumi Takahashi, Hiroki Ida, Yoshiharu Matsumae, Hirokazu Komaki, Yuanshu Zhou, Akichika Kumatani, Makoto Kanzaki, Hitoshi Shiku, Tomokazu Matsue

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Local cell-membrane permeability and ionic strength are important factors for maintaining the functions of cells. Here, we measured the spatial electrochemical and ion concentration profile near the sample surface with nanoscale resolution using scanning electrochemical microscopy (SECM) combined with scanning ion-conductance microscopy (SICM). The ion current feedback system is an effective way to control probe-sample distance without contact and monitor the kinetic effect of mediator regeneration and the chemical concentration profile. For demonstrating 3D electrochemical and ion concentration mapping, we evaluated the reaction rate of electrochemical mediator regeneration on an unbiased conductor and visualized inhomogeneous permeability and the ion concentration 3D profile on a single fixed adipocyte cell surface.

本文言語English
ページ(範囲)26728-26733
ページ数6
ジャーナルPhysical Chemistry Chemical Physics
19
39
DOI
出版ステータスPublished - 2017

ASJC Scopus subject areas

  • 物理学および天文学(全般)
  • 物理化学および理論化学

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