3β-Hydroxysteroid dehydrogenase in human aorta

Yasuhiro Nakamura, Takashi Suzuki, Tsukasa Inoue, Chika Tazawa, Takuya Moriya, Haruo Saito, Tadashi Ishibashi, Shoki Takahashi, Shogo Yamada, Hironobu Sasano

研究成果: Article査読

6 被引用数 (Scopus)

抄録

3β-hydroxysteroid dehydrogenase (3β-HSD) is known to be involved in steroid production and/or metabolism and to be expressed in many tissues including adrenal cortex. Expression of this enzyme has also been elucidated in human cardiovascular system but its details remain largely unknown. Therefore, in this study, we examined the status of 3β-HSD in postmortem human aorta utilizing RT-PCR and immunohistochemical analysis. Both mRNAs and immunoreactivity for the enzyme were detected predominantly in female aorta, and in those with mild atherosclerotic changes. In addition, immunohistochemical study demonstrated that immunoreactivity for 3β-HSD was detected in vascular smooth muscle cells (VSMCs) of aorta. These findings all indicated that steroidogenesis via 3β-HSD may occur in VSMCs of human aorta, possibly related to gender differences and/or the degree of atherosclerosis.

本文言語English
ページ(範囲)111-115
ページ数5
ジャーナルendocrine journal
52
1
DOI
出版ステータスPublished - 2005 2

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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