2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.

Hiroshi Ohrui, Satoru Kohgo, Hiroyuki Hayakawa, Eiichi Kodama, Masao Matsuoka, Tomohiro Nakata, Hiroyuki Mitsuya

研究成果: Article査読

15 被引用数 (Scopus)

抄録

A working hypothesis to solve the critical problems of existing HAART was proposed. The study based on the hypothesis proved the validity of the hypothesis and resulted in the development of 2'-deoxy-4'-C-ethynyl-2-fluoro-adenosine (4'Ed2FA), a nucleoside reverse transcriptase inhibitor (NRTI) with highly potent activity against all HIV-1 strains, very favourable toxic profiles, and stability in plasma.

本文言語English
ページ(範囲)1-2
ページ数2
ジャーナルNucleic acids symposium series (2004)
50
DOI
出版ステータスPublished - 2006
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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