TY - JOUR
T1 - 17β-Hydroxysteroid dehydrogenases in human endometrium and its disorders
AU - Ito, Kiyoshi
AU - Utsunomiya, Hiroki
AU - Suzuki, Takashi
AU - Saitou, Sumika
AU - Akahira, Jun Ichi
AU - Okamura, Kunihiro
AU - Yaegashi, Nobuo
AU - Sasano, Hironobu
PY - 2006/3/27
Y1 - 2006/3/27
N2 - In situ estrogen metabolism and synthesis have been considered to play a very important role in the development and progression of human endometrial carcinoma. 17β-Hydroxysteroid dehydrogenases (17-HSDs) are enzymes involved in the formation of active sex steroids, including testosterone, estrone (E1) and estradiol (E2). Estrogens are interchanged by two enzymes, 17-HSD types 1 and 2, type 1 converts E1 to E2, and type 2 does reverse actions. 17-HSD type 5 catalyzes the reduction of androstenedione to testosterone. 17-HSD type 2 expression was decreased through normal endometrium, hyperplasia and carcinoma accordingly. There was a significant inverse correlation between intratumoral E2 concentration and the level of 17-HSD type 2 mRNA in endometrial carcinoma. 17-HSD type 5 expression was significantly increased through normal endometrium, hyperplasia and carcinoma accordingly. These results indicated that 17-HSD types 2 and 5 play an important role in the regulation of in situ estrogen production in endometrial carcinoma.
AB - In situ estrogen metabolism and synthesis have been considered to play a very important role in the development and progression of human endometrial carcinoma. 17β-Hydroxysteroid dehydrogenases (17-HSDs) are enzymes involved in the formation of active sex steroids, including testosterone, estrone (E1) and estradiol (E2). Estrogens are interchanged by two enzymes, 17-HSD types 1 and 2, type 1 converts E1 to E2, and type 2 does reverse actions. 17-HSD type 5 catalyzes the reduction of androstenedione to testosterone. 17-HSD type 2 expression was decreased through normal endometrium, hyperplasia and carcinoma accordingly. There was a significant inverse correlation between intratumoral E2 concentration and the level of 17-HSD type 2 mRNA in endometrial carcinoma. 17-HSD type 5 expression was significantly increased through normal endometrium, hyperplasia and carcinoma accordingly. These results indicated that 17-HSD types 2 and 5 play an important role in the regulation of in situ estrogen production in endometrial carcinoma.
KW - 17β-Hydroxysteroid dehydrogenases
KW - Cancer
KW - Endometrium
KW - Estrogen
KW - Testosterone
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U2 - 10.1016/j.mce.2005.11.038
DO - 10.1016/j.mce.2005.11.038
M3 - Article
C2 - 16406263
AN - SCOPUS:33644891602
VL - 248
SP - 136
EP - 140
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1-2
ER -
