17β-hydroxysteroid dehydrogenase in common epithelial ovarian tumors

Hironobu Sasano, Takashi Suzuki, Hitoshi Niikura, Keiko Kaga, Shinji Sato, Akira Yajima, William E. Rainey, Hiroshi Nagura

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Type 1 17β-hydroxysteroid dehydrogenase (17β-HSD) is an estrogen-metabolizing enzyme that catalyzes the conversion of estrone to the more biologically potent estradiol. We examined the immunolocalization of 17β-HSD in five specimens of normal human ovary and in 51 specimens of common epithelial tumors of the ovary to study the expression of 17β-HSD in these ovarian neoplasms. 17β-HSD immunoreactivity was detected in granulosa cells of dominant preantral follicles but not in the surface epithelium of the normal cycling human ovary. In 12 patients, the enzyme was not expressed in tumor cells of benign cystadenoma 17β-HSD was immunolocalized in the cytoplasm of four specimens (50%) of eight of tumors of low malignant potential and in 20 specimens (67%) of 30 of invasive carcinoma 17β-HSD immunoreactivity was also observed in nonluteinized stromal cells of mucinous tumors (two adenomas of six, three tumors of five with low malignant potential, and two of 10 invasive carcinomas) but not in other histologic types. Type 1 17β-HSD expression, therefore, correlated with malignant transformation of the surface epithelium of the human ovary, supporting a possible role in its progression by increasing in situ estradiol concentration.

本文言語English
ページ(範囲)386-391
ページ数6
ジャーナルModern Pathology
9
4
出版ステータスPublished - 1996 4

ASJC Scopus subject areas

  • 病理学および法医学

フィンガープリント

「17β-hydroxysteroid dehydrogenase in common epithelial ovarian tumors」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル