11β-Hydroxysteroid dehydrogenase type 2 in human lung: Possible regulator of mineralocorticoid action

Takashi Suzuki, Hironobu Sasano, Satoshi Suzuki, Gen Hirasawa, Junji Takeyama, Yasunari Muramatsu, Fumiko Date, Hiroshi Nagura, Zygmunt S. Krozowski

研究成果: Article査読

52 被引用数 (Scopus)

抄録

11β-Hydroxysteroid dehydrogenase type 2 (11βHSD2) catalyzes the conversion of cortisol to biologically inactive cortisone and is thought to confer specificity on mineralocorticoid receptors (MR). Cortisol is a prerequisite for surfactant synthesis and fetal lung maturation. Recently, expression of 11βHSD2 was demonstrated in human fetal lung, but its localization and possible biological roles remain unknown. Therefore, in this study, we examined immunohistochemical localization of 11βHSD2, MR, and glucocorticoid receptor (GR) in nonpathological human lungs from fetus to adult (8 weeks gestation to 55 yr of age; n = 40) retrieved from pathology files. Both 11βHSD2 and MR immunoreactivities were detected in airway epithelia, from bronchiole to trachea and in fetal and neonatal ciliated collecting duct cells of tracheal and bronchial glands, but were undetectable in alveoli. On the other hand, GR was detected in all cell types. These results indicate that 11βHSD2 colocalizes with MR in human airway epithelia and suggest that 11βHSD2 play an important role in pulmonary mineralocorticoid activity such as sodium and fluid transport.

本文言語English
ページ(範囲)4022-4025
ページ数4
ジャーナルJournal of Clinical Endocrinology and Metabolism
83
11
DOI
出版ステータスPublished - 1998

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 内分泌学
  • 臨床生化学
  • 生化学、医学

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