β-nerve growth factor as a mediator of the acute phase response in vivo

Katsunori Nonogaki, Arthur H. Moser, Judy Shigenaga, Kenneth R. Feingold, Carl Grunfeld

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Nerve growth factor (NGF) is increased during inflammation and stress, Stress-induced increases in specific serum proteins, such as serum amyloid A (SAA) and serum triglyceride (TG) levels, are part of tile acute phase response which is mediated by cytokines. We now report the effect of systemic administration of β-NGF on levels of serum lipids and SAA. β-NGF induced a rapid and sustained increase in serum TG and free fatty acid (FFA) in a dose dependent manner, while decreasing serum cholesterol levels in rats. Additionally, β-NGF increased hepatic mRNA levels and serum concentrations of SAA at 16 hours in mice. Thus, β-NGF joins the list of cytokines and growth factors that can mediate the acute phase response.

本文言語English
ページ(範囲)956-961
ページ数6
ジャーナルBiochemical and biophysical research communications
219
3
DOI
出版ステータスPublished - 1996 2月 27
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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