TY - JOUR
T1 - β-nerve growth factor as a mediator of the acute phase response in vivo
AU - Nonogaki, Katsunori
AU - Moser, Arthur H.
AU - Shigenaga, Judy
AU - Feingold, Kenneth R.
AU - Grunfeld, Carl
N1 - Funding Information:
We thank Dr. Nobuo Sakamoto for his interest in our work. This work was supported by grants from the Research Service of the Department of Veterans Affairs and the Third Department of Internal Medicine, Nagoya University School of Medicine.
PY - 1996/2/27
Y1 - 1996/2/27
N2 - Nerve growth factor (NGF) is increased during inflammation and stress, Stress-induced increases in specific serum proteins, such as serum amyloid A (SAA) and serum triglyceride (TG) levels, are part of tile acute phase response which is mediated by cytokines. We now report the effect of systemic administration of β-NGF on levels of serum lipids and SAA. β-NGF induced a rapid and sustained increase in serum TG and free fatty acid (FFA) in a dose dependent manner, while decreasing serum cholesterol levels in rats. Additionally, β-NGF increased hepatic mRNA levels and serum concentrations of SAA at 16 hours in mice. Thus, β-NGF joins the list of cytokines and growth factors that can mediate the acute phase response.
AB - Nerve growth factor (NGF) is increased during inflammation and stress, Stress-induced increases in specific serum proteins, such as serum amyloid A (SAA) and serum triglyceride (TG) levels, are part of tile acute phase response which is mediated by cytokines. We now report the effect of systemic administration of β-NGF on levels of serum lipids and SAA. β-NGF induced a rapid and sustained increase in serum TG and free fatty acid (FFA) in a dose dependent manner, while decreasing serum cholesterol levels in rats. Additionally, β-NGF increased hepatic mRNA levels and serum concentrations of SAA at 16 hours in mice. Thus, β-NGF joins the list of cytokines and growth factors that can mediate the acute phase response.
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U2 - 10.1006/bbrc.1996.0325
DO - 10.1006/bbrc.1996.0325
M3 - Article
C2 - 8645286
AN - SCOPUS:0029670161
VL - 219
SP - 956
EP - 961
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -