α2-Macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease

Susumu Higuchi, Sachio Matsushita, Jun Nakane, Hiroyuki Arai, Toshifumi Matsui, Katsuya Urakami, Takefumi Yuzuriha, Atsushi Takeda

研究成果: Article

19 引用 (Scopus)

抜粋

Two genetic markers of the plasma protein α2-macroglobulin, a 5 bp deletion/insertion at the 5' splice site of exon 18 (A2M1) and the GTC/ATC (Val1000I1e) in exon 24 (A2M2), may have roles in the development of Alzheimer's disease (AD). Genotyping and linkage analysis of these markers in 426 Japanese sporadic AD patients, 85 autopsy-confirmed Caucasian AD cases, and, as controls, 382 Japanese and 65 Caucasians who were cognitively normal and 140 Japanese Parkinson's disease patients showed racial diversity in the frequencies and relationship of the two markers. Comparison of genotype and allele frequencies, stratification of the samples by the presence of the apolipoprotein E ε4 allele, and logistic regression analysis revealed no association of these markers with AD in either racial group. (C) 2000 Lippincott Williams and Wilkins.

元の言語English
ページ(範囲)1167-1171
ページ数5
ジャーナルNeuroReport
11
発行部数6
DOI
出版物ステータスPublished - 2000 4 27

ASJC Scopus subject areas

  • Neuroscience(all)

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    Higuchi, S., Matsushita, S., Nakane, J., Arai, H., Matsui, T., Urakami, K., Yuzuriha, T., & Takeda, A. (2000). α2-Macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease. NeuroReport, 11(6), 1167-1171. https://doi.org/10.1097/00001756-200004270-00005