年別の研究成果
年別の研究成果
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2023
Convergent and Scalable Synthesis of the ABCDE-Ring Fragment of Caribbean Ciguatoxin C-CTX-1
Sasaki, M., Seida, M. & Umehara, A., 2023 1月 6, In: Journal of Organic Chemistry. 88, 1, p. 403-418 16 p.研究成果: Article › 査読
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DMAPO/Boc2O-Mediated One-Pot Direct N-Acylation of Less Nucleophilic N-Heterocycles with Carboxylic Acids
Umehara, A., Shimizu, S. & Sasaki, M., 2023 3月 8, In: ChemCatChem. 15, 5, e202201596.研究成果: Article › 査読
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2022
Convergent Synthesis of the HIJKLMN-Ring Fragment of Caribbean Ciguatoxin C-CTX-1 by a Late-Stage Reductive Olefin Coupling Approach
Sasaki, M., Iwasaki, K., Arai, K., Hamada, N. & Umehara, A., 2022 5月, In: Bulletin of the Chemical Society of Japan. 95, 5, p. 819-824 6 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
Raposo-Garcia, S., Louzao, M. C., Fuwa, H., Sasaki, M., Vale, C. & Botana, L. M., 2022 2月, In: Food and Chemical Toxicology. 160, 112812.研究成果: Article › 査読
Open Access5 被引用数 (Scopus) -
Gambierol Blocks a K+ Current Fraction without Affecting Catecholamine Release in Rat Fetal Adrenomedullary Cultured Chromaffin Cells
Benoit, E., Schlumberger, S., Molgó, J., Sasaki, M., Fuwa, H. & Bournaud, R., 2022 4月, In: Toxins. 14, 4, 254.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
2021
Synthesis and Structural Implication of the JKLMN-Ring Fragment of Caribbean Ciguatoxin C-CTX-1
Sasaki, M., Iwasaki, K. & Arai, K., 2021 3月 19, In: Journal of Organic Chemistry. 86, 6, p. 4580-4597 18 p.研究成果: Article › 査読
5 被引用数 (Scopus) -
2020
Gambierol Potently Increases Evoked Quantal Transmitter Release and Reverses Pre- and Post-Synaptic Blockade at Vertebrate Neuromuscular Junctions
Molgó, J., Schlumberger, S., Sasaki, M., Fuwa, H., Louzao, M. C., Botana, L. M., Servent, D. & Benoit, E., 2020 7月 15, In: Neuroscience. 439, p. 106-116 11 p.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
Unified Total Synthesis of (−)-Enigmazole A and (−)-15-O-Methylenigmazole A
Sakurai, K., Sakamoto, K., Sasaki, M. & Fuwa, H., 2020 11月 2, In: Chemistry - An Asian Journal. 15, 21, p. 3494-3502 9 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
2019
Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging
Yanagi, S., Sugai, T., Noguchi, T., Kawakami, M., Sasaki, M., Niwa, S., Sugimoto, A. & Fuwa, H., 2019, In: Organic and Biomolecular Chemistry. 17, 28, p. 6771-6776 6 p.研究成果: Article › 査読
4 被引用数 (Scopus) -
2018
Studies toward the Total Synthesis of Caribbean Ciguatoxin C-CTX-1: Synthesis of the LMN-Ring Fragment through Reductive Olefin Cross-Coupling
Sasaki, M., Iwasaki, K. & Arai, K., 2018 11月 16, In: Organic letters. 20, 22, p. 7163-7166 4 p.研究成果: Article › 査読
9 被引用数 (Scopus) -
Total Synthesis of (−)-Enigmazole A
Sakurai, K., Sasaki, M. & Fuwa, H., 2018 4月 23, In: Angewandte Chemie - International Edition. 57, 18, p. 5143-5146 4 p.研究成果: Article › 査読
21 被引用数 (Scopus) -
2017
Tetracyclic Truncated Analogue of the Marine Toxin Gambierol Modifies NMDA, Tau, and Amyloid β Expression in Mice Brains: Implications in AD Pathology
Alonso, E., Vieira, A. C., Rodriguez, I., Alvariño, R., Gegunde, S., Fuwa, H., Suga, Y., Sasaki, M., Alfonso, A., Cifuentes, J. M. & Botana, L. M., 2017 6月 21, In: ACS Chemical Neuroscience. 8, 6, p. 1358-1367 10 p.研究成果: Article › 査読
15 被引用数 (Scopus) -
Total Synthesis of Polycavernosides A and B, Two Lethal Toxins from Red Alga
Iwasaki, K., Sasaki, S., Kasai, Y., Kawashima, Y., Sasaki, S., Ito, T., Yotsu-Yamashita, M. & Sasaki, M., 2017 12月 15, In: Journal of Organic Chemistry. 82, 24, p. 13204-13219 16 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
2016
Complete Stereochemical Assignment of Campechic Acids A and B
Isaka, R., Yu, L., Sasaki, M., Igarashi, Y. & Fuwa, H., 2016 5月 6, In: Journal of Organic Chemistry. 81, 9, p. 3638-3647 10 p.研究成果: Article › 査読
5 被引用数 (Scopus) -
Cytotoxicity of goniodomin A and B in non contractile cells
Espiña, B., Cagide, E., Louzao, M. C., Vilariño, N., Vieytes, M. R., Takeda, Y., Sasaki, M. & Botana, L. M., 2016 5月 27, In: Toxicology Letters. 250-251, p. 10-20 11 p.研究成果: Article › 査読
15 被引用数 (Scopus) -
Diastereoselective Ring-Closing Metathesis as a Means to Construct Medium-Sized Cyclic Ethers: Application to the Synthesis of a Photoactivatable Gambierol Derivative
Onodera, Y., Hirota, K., Suga, Y., Konoki, K., Yotsu-Yamashita, M., Sasaki, M. & Fuwa, H., 2016 9月 16, In: Journal of Organic Chemistry. 81, 18, p. 8234-8252 19 p.研究成果: Article › 査読
7 被引用数 (Scopus) -
Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid
Furumochi, S., Onoda, T., Cho, Y., Fuwa, H., Sasaki, M., Yotsu-Yamashita, M. & Konoki, K., 2016 7月 1, In: Bioorganic and Medicinal Chemistry Letters. 26, 13, p. 2992-2996 5 p.研究成果: Article › 査読
5 被引用数 (Scopus) -
Exploiting ruthenium carbene-catalyzed reactions in total synthesis of marine oxacyclic natural products
Fuwa, H. & Sasaki, M., 2016, In: Bulletin of the Chemical Society of Japan. 89, 12, p. 1403-1415 13 p.研究成果: Article › 査読
Open Access17 被引用数 (Scopus) -
Progress toward the Total Synthesis of Goniodomin A: Stereocontrolled, Convergent Synthesis of the C12-C36 Fragment
Fuwa, H., Matsukida, S., Miyoshi, T., Kawashima, Y., Saito, T. & Sasaki, M., 2016 3月 18, In: Journal of Organic Chemistry. 81, 6, p. 2213-2227 15 p.研究成果: Article › 査読
15 被引用数 (Scopus) -
Stereodivergent Synthesis and Configurational Assignment of the C1-C15 Segment of Amphirionin-5
Kanto, M., Sato, S., Tsuda, M. & Sasaki, M., 2016 10月 7, In: Journal of Organic Chemistry. 81, 19, p. 9105-9121 17 p.研究成果: Article › 査読
10 被引用数 (Scopus) -
Synthetic Studies on Amphirionin-5: Stereochemical Assignment/Reassignment of the C1-C9 Portion through Stereodivergent Synthesis
Kanto, M. & Sasaki, M., 2016 1月 4, In: Organic letters. 18, 1, p. 112-115 4 p.研究成果: Article › 査読
10 被引用数 (Scopus) -
Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (-)-Lyngbyaloside B
Fuwa, H., Yamagata, N., Okuaki, Y., Ogata, Y., Saito, A. & Sasaki, M., 2016 5月 10, In: Chemistry - A European Journal. 22, 20, p. 6815-6829 15 p.研究成果: Article › 査読
16 被引用数 (Scopus) -
Toward a total synthesis of amphidinolide N: convergent synthesis of the C1–C13 segment
Toyoshima, A. & Sasaki, M., 2016, In: Tetrahedron Letters. 57, 31, p. 3532-3534 3 p.研究成果: Article › 査読
7 被引用数 (Scopus) -
Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8-C29 Fragment
Kawashima, Y., Toyoshima, A., Fuwa, H. & Sasaki, M., 2016 5月 6, In: Organic letters. 18, 9, p. 2232-2235 4 p.研究成果: Article › 査読
10 被引用数 (Scopus) -
2015
Concise synthesis of the C15-C38 fragment of okadaic acid: Application of the Suzuki-Miyaura reaction to spiroacetal synthesis
Fuwa, H., Sakamoto, K., Muto, T. & Sasaki, M., 2015 1月 16, In: Organic letters. 17, 2, p. 366-369 4 p.研究成果: Article › 査読
5 被引用数 (Scopus) -
Concise synthesis of the C15-C38 fragment of okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A
Fuwa, H., Sakamoto, K., Muto, T. & Sasaki, M., 2015 8月 7, In: Tetrahedron. 71, 37, p. 6369-6383 15 p., 26603.研究成果: Article › 査読
6 被引用数 (Scopus) -
Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity
Konoki, K., Suga, Y., Fuwa, H., Yotsu-Yamashita, M. & Sasaki, M., 2015 2月 1, In: Bioorganic and Medicinal Chemistry Letters. 25, 3, p. 514-518 5 p.研究成果: Article › 査読
10 被引用数 (Scopus) -
Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation
Rubiolo, J. A., Vale, C., Martín, V., Fuwa, H., Sasaki, M. & Botana, L. M., 2015 7月 15, In: Archives of Toxicology. 89, 7, p. 1119-1134 16 p.研究成果: Article › 査読
17 被引用数 (Scopus) -
Studies toward the total synthesis of amphidinolide n: stereocontrolled synthesis of the c13-c29 segment
Sasaki, M., Kawashima, Y. & Fuwa, H., 2015, In: Heterocycles. 90, 1, p. 579-599 21 p.研究成果: Article › 査読
9 被引用数 (Scopus) -
Total synthesis, stereochemical reassignment, and biological evaluation of (-)-lyngbyaloside B
Fuwa, H., Okuaki, Y., Yamagata, N. & Sasaki, M., 2015 1月 12, In: Angewandte Chemie - International Edition. 54, 3, p. 868-873 6 p.研究成果: Article › 査読
22 被引用数 (Scopus) -
2014
Programmed cell death induced by (-)-8,9-dehydroneopeltolide in human promyelocytic leukemia HL-60 cells under energy stress conditions
Fuwa, H., Sato, M. & Sasaki, M., 2014 11月 20, In: Marine Drugs. 12, 11, p. 5576-5589 14 p.研究成果: Article › 査読
8 被引用数 (Scopus) -
Stereoselective synthesis of medium-sized cyclic ethers: Application of C -glycosylation chemistry to seven- to nine-membered lactone-derived thioacetals and their sulfone counterparts
Suga, Y., Fuwa, H. & Sasaki, M., 2014 2月 21, In: Journal of Organic Chemistry. 79, 4, p. 1656-1682 27 p.研究成果: Article › 査読
8 被引用数 (Scopus) -
Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain
Fuwa, H., Noguchi, T., Kawakami, M. & Sasaki, M., 2014 6月 1, In: Bioorganic and Medicinal Chemistry Letters. 24, 11, p. 2415-2419 5 p.研究成果: Article › 査読
22 被引用数 (Scopus) -
Total synthesis and structure revision of didemnaketalB
Fuwa, H., Muto, T., Sekine, K. & Sasaki, M., 2014 2月 10, In: Chemistry - A European Journal. 20, 7, p. 1848-1860 13 p.研究成果: Article › 査読
30 被引用数 (Scopus) -
2013
Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: Identification of pharmacophoric elements
Fuwa, H., Kawakami, M., Noto, K., Muto, T., Suga, Y., Konoki, K., Yotsu-Yamashita, M. & Sasaki, M., 2013 6月 17, In: Chemistry - A European Journal. 19, 25, p. 8100-8110 11 p.研究成果: Article › 査読
41 被引用数 (Scopus) -
Synthesis and biological evaluation of aspergillide a/neopeltolide chimeras
Fuwa, H., Noto, K., Kawakami, M. & Sasaki, M., 2013, In: Chemistry Letters. 42, 9, p. 1020-1022 3 p.研究成果: Article › 査読
5 被引用数 (Scopus) -
Total synthesis and biological evaluation of (-)-exiguolide analogues: Importance of the macrocyclic backbone
Fuwa, H., Mizunuma, K., Sasaki, M., Suzuki, T. & Kubo, H., 2013 6月 7, In: Organic and Biomolecular Chemistry. 11, 21, p. 3442-3450 9 p.研究成果: Article › 査読
21 被引用数 (Scopus) -
Total synthesis and biological evaluation of (+)-gambieric acid A and its analogues
Ishigai, K., Fuwa, H., Hashizume, K., Fukazawa, R., Cho, Y., Yotsu-Yamashita, M. & Sasaki, M., 2013 4月 22, In: Chemistry - A European Journal. 19, 17, p. 5276-5288 13 p.研究成果: Article › 査読
33 被引用数 (Scopus) -
Total synthesis of 13-demethyllyngbyaloside B
Fuwa, H., Yamagata, N., Saito, A. & Sasaki, M., 2013 4月 5, In: Organic letters. 15, 7, p. 1630-1633 4 p.研究成果: Article › 査読
19 被引用数 (Scopus) -
Total synthesis of the proposed structure of didemnaketal B
Fuwa, H., Sekine, K. & Sasaki, M., 2013 8月 2, In: Organic letters. 15, 15, p. 3970-3973 4 p.研究成果: Article › 査読
14 被引用数 (Scopus) -
2012
A concise synthesis of the ab-ring fragment of (-)-gambierol
Fuwa, H., Hirota, K. & Sasaki, M., 2012, In: Heterocycles. 86, 1, p. 127-132 6 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
Design and synthesis of skeletal analogues of gambierol: Attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-Methyl-d-aspartate receptor implications
Alonso, E., Fuwa, H., Vale, C., Suga, Y., Goto, T., Konno, Y., Sasaki, M., Laferla, F. M., Vieytes, M. R., Giménez-Llort, L. & Botana, L. M., 2012 5月 2, In: Journal of the American Chemical Society. 134, 17, p. 7467-7479 13 p.研究成果: Article › 査読
57 被引用数 (Scopus) -
Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: A structure-activity relationships study
Pérez, S., Vale, C., Alonso, E., Fuwa, H., Sasaki, M., Konno, Y., Goto, T., Suga, Y., Vieytes, M. R. & Botana, L. M., 2012 9月 17, In: Chemical Research in Toxicology. 25, 9, p. 1929-1937 9 p.研究成果: Article › 査読
24 被引用数 (Scopus) -
Stereoselective synthesis of 2,6- cis -substituted tetrahydropyrans: Brønsted acid-catalyzed intramolecular oxa-conjugate cyclization of α,β-unsaturated ester surrogates
Fuwa, H., Ichinokawa, N., Noto, K. & Sasaki, M., 2012 3月 16, In: Journal of Organic Chemistry. 77, 6, p. 2588-2607 20 p.研究成果: Article › 査読
54 被引用数 (Scopus) -
Stereoselective synthesis of the C1-C16 fragment of goniodomin A
Nakajima, M., Fuwa, H. & Sasaki, M., 2012, In: Bulletin of the Chemical Society of Japan. 85, 9, p. 948-956 9 p.研究成果: Article › 査読
7 被引用数 (Scopus) -
Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: Concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives
Fuwa, H., Noguchi, T., Noto, K. & Sasaki, M., 2012 10月 28, In: Organic and Biomolecular Chemistry. 10, 40, p. 8108-8112 5 p.研究成果: Article › 査読
32 被引用数 (Scopus) -
Total synthesis and complete stereostructure of gambieric acid A
Fuwa, H., Ishigai, K., Hashizume, K. & Sasaki, M., 2012 7月 25, In: Journal of the American Chemical Society. 134, 29, p. 11984-11987 4 p.研究成果: Article › 査読
58 被引用数 (Scopus) -
Total synthesis of (-)-polycavernoside A: Suzuki-Miyaura coupling approach
Kasai, Y., Ito, T. & Sasaki, M., 2012 6月 15, In: Organic letters. 14, 12, p. 3186-3189 4 p.研究成果: Article › 査読
23 被引用数 (Scopus) -
2011
A convergent synthesis of the C1-C16 segment of goniodomin A via palladium-catalyzed organostannane-thioester coupling
Fuwa, H., Nakajima, M., Shi, J., Takeda, Y., Saito, T. & Sasaki, M., 2011 3月 4, In: Organic letters. 13, 5, p. 1106-1109 4 p.研究成果: Article › 査読
26 被引用数 (Scopus) -
A new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrones via palladium-catalyzed coupling of thioesters
Fuwa, H., Mizunuma, K., Matsukida, S. & Sasaki, M., 2011 7月 8, In: Tetrahedron. 67, 27-28, p. 4995-5010 16 p.研究成果: Article › 査読
30 被引用数 (Scopus)