TY - JOUR
T1 - Zollinger-ellison syndrome
T2 - A study of four cases with special reference to gut hormones
AU - Imamura, Mikio
AU - Kameyama, Jin Ichi
AU - Sasaki, Iwao
AU - Narui, Hideo
AU - Naito, Hiroo
AU - Tsuchiya, Takashi
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Four cases of Zollinger-Ellison syndrome were investigated from the perspective of gut hormones, with special emphasis on various kinds of provocation tests. None of these cases was diagnosed as Zollinger-Ellison syndrome at the time of the first operation for peptic ulcer. In all cases, peptic ulcer recurred and so, then, various kinds of provocation tests were performed. Thereafter, they were all diagnosed as Zollinger-Ellison syndrome. Fasting levels of plasma gastrin were not always high in these cases, however, they showed positive responses to the secretin, glucagon and calcium provocation tests. Moreover, plasma gastrin levels increased remarkably after test-meal loading. In regard to the method of the secretin provocation test, an initial bolus injection of secretin (3 u/kg) followed by a continuous infusion of the same dose for one hour is a recommendable one. In those cases with both Zollinger-Ellison syndrome and duodenal ulcer, plasma motilin levels increased markedly in the secretin provocation test.
AB - Four cases of Zollinger-Ellison syndrome were investigated from the perspective of gut hormones, with special emphasis on various kinds of provocation tests. None of these cases was diagnosed as Zollinger-Ellison syndrome at the time of the first operation for peptic ulcer. In all cases, peptic ulcer recurred and so, then, various kinds of provocation tests were performed. Thereafter, they were all diagnosed as Zollinger-Ellison syndrome. Fasting levels of plasma gastrin were not always high in these cases, however, they showed positive responses to the secretin, glucagon and calcium provocation tests. Moreover, plasma gastrin levels increased remarkably after test-meal loading. In regard to the method of the secretin provocation test, an initial bolus injection of secretin (3 u/kg) followed by a continuous infusion of the same dose for one hour is a recommendable one. In those cases with both Zollinger-Ellison syndrome and duodenal ulcer, plasma motilin levels increased markedly in the secretin provocation test.
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U2 - 10.11405/nisshoshi1964.81.1181
DO - 10.11405/nisshoshi1964.81.1181
M3 - Article
C2 - 6471531
AN - SCOPUS:0021233849
VL - 81
SP - 1181
EP - 1190
JO - Journal of Japanese Society of Gastroenterology
JF - Journal of Japanese Society of Gastroenterology
SN - 0446-6586
IS - 5
ER -