TY - JOUR
T1 - Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum
AU - Kabuto, Hideaki
AU - Nishizawa, Masahiro
AU - Tada, Mika
AU - Higashio, Chie
AU - Shishibori, Tsuyoshi
AU - Kohno, Masahiro
PY - 2005/3
Y1 - 2005/3
N2 - As superoxide (•O2-) and hydroxyl radical (•OH) have been implicated in pathogenesis of Parkinson's disease, free radical scavenging, antioxidant, and neuroprotective agents have attracted attention as ways to prevent progression. We examined effects of zingerone, an alkaloid extracted from ginger root, on 6-hydroxydopamine (6-OHDA)-induced dopamine (DA) reduction in mouse striatum. Zingerone administration 1 h before and for 6 more days following one intracerebroventricular 6-OHDA injection prevented reductions of striatal DA and its metabolites, and increased serum •O2- scavenging activity. Zingerone did not change activities of catalase or glutathione peroxidase in striatum or serum, or •O2- scavenging activity in striatum. Treatment with diethyldithiocarbamate, SOD inhibitor, abolished the protective effect of zingerone against 6-OHDA-induced DA reduction. In vitro, zingerone scavenged •O2- and •OH and suppressed lipid peroxidation only weakly. Thus, direct antioxidant effects may be a minor component of its putative neuroprotective effect; instead, zingerone acted mainly by increasing systemic superoxide dismutase activity. Effects of zingerone treatment in this model suggest possible value in treatment of Parkinson's disease.
AB - As superoxide (•O2-) and hydroxyl radical (•OH) have been implicated in pathogenesis of Parkinson's disease, free radical scavenging, antioxidant, and neuroprotective agents have attracted attention as ways to prevent progression. We examined effects of zingerone, an alkaloid extracted from ginger root, on 6-hydroxydopamine (6-OHDA)-induced dopamine (DA) reduction in mouse striatum. Zingerone administration 1 h before and for 6 more days following one intracerebroventricular 6-OHDA injection prevented reductions of striatal DA and its metabolites, and increased serum •O2- scavenging activity. Zingerone did not change activities of catalase or glutathione peroxidase in striatum or serum, or •O2- scavenging activity in striatum. Treatment with diethyldithiocarbamate, SOD inhibitor, abolished the protective effect of zingerone against 6-OHDA-induced DA reduction. In vitro, zingerone scavenged •O2- and •OH and suppressed lipid peroxidation only weakly. Thus, direct antioxidant effects may be a minor component of its putative neuroprotective effect; instead, zingerone acted mainly by increasing systemic superoxide dismutase activity. Effects of zingerone treatment in this model suggest possible value in treatment of Parkinson's disease.
KW - Antioxidants
KW - Dopamine
KW - Parkinson's disease
KW - Superoxide scavenging activity
KW - Zingerone
UR - http://www.scopus.com/inward/record.url?scp=21144458114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21144458114&partnerID=8YFLogxK
U2 - 10.1007/s11064-005-2606-3
DO - 10.1007/s11064-005-2606-3
M3 - Article
C2 - 16018576
AN - SCOPUS:21144458114
VL - 30
SP - 325
EP - 332
JO - Neurochemical Research
JF - Neurochemical Research
SN - 0364-3190
IS - 3
ER -