Zinc deficiency causes to decrease plasma calcium and ionized calcium concentrations prior to an increase in the plasma parathyroid hormone concentration in rats

Tomoko Goto, Hitoshi Shirakawa, Michio Komai

Research output: Contribution to journalArticle

Abstract

The effects of zinc deficiency on plasma calcium and ionized calcium concentrations were examined in rats. We monitored plasma concentrations of calcium, ionized calcium (Ca2+), parathyroid hormone (PTH) and ionized magnesium (Mg2+) in male 4 week-old Sprague-Dawley rats, that were divided into three groups: zinc-deficient (Zn-Def), low-zinc (Low-Zn), and control pair-fed to Zn-Def (Pair-fed) groups, for 28 days. Comparing to Pair-fed rats, plasma calcium and Ca2+ concentrations of Zn-Def rats were found to be significantly lower after 4, 14, 21, 28 days of feeding. There was no significant change of the plasma Mg2+ concentration among three groups. Comparing to Pair-fed rats, the plasma PTH concentration in Zn-Def rats tended to be higher after 21 days of feeding, and significantly higher after 28 days of feeding. The results suggest that zinc deficiency causes to decrease plasma calcium and Ca2+ concentrations prior to an increase of the plasma PTH concentration.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalNano Biomedicine
Volume8
Issue number2
Publication statusPublished - 2016 Jan 1

Keywords

  • Calcium
  • Parathyroid hormone
  • Rats
  • Zinc

ASJC Scopus subject areas

  • Biomedical Engineering

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