Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer Registry

Akemi Kataoka, Takayuki Iwamoto, Eriko Tokunaga, Ai Tomotaki, Hiraku Kumamaru, Hiroaki Miyata, Naoki Niikura, Masaaki Kawai, Keisei Anan, Naoki Hayashi, Shinobu Masuda, Koichiro Tsugawa, Kenjiro Aogi, Takanori Ishida, Hideji Masuoka, Kotaro Iijima, Takayuki Kinoshita, Seigo Nakamura, Yutaka Tokuda

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: The aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors. Methods: Of the 53,670 patients registered between 2004 and 2006 and surveyed after a 5-year follow-up prognosis, 25,898 breast cancer patients (48.3 %), who were obtained prognostic data, were examined. Clinicopathological factors were compared between young adult (YA; <35 years), middle-aged adult (MA; 35–50 years), and older adult (OA; >50 years) patients. Five-year disease-free survival (DFS) and overall survival (OS) rates were studied. Results: YA patients were associated with an advanced TNM stage and aggressive characteristics (e.g. human epidermal growth factor receptor 2 (HER2)-positive or oestrogen receptor (ER)-negative breast cancers) compared to MA and OA patients (P < 0.001). The 5-year DFS and OS rates were 79.4 % and 90.8, 88.5 and 95.0 %, and 87.8 % and 91.6 % for YA, MA, and OA patients, respectively. From the multivariable regression analysis, young age at onset was confirmed as an independent prognostic factor for both DFS (hazard ratio 1.73, 95 % confidence interval 1.42–2.10; P < 0.001) and OS (hazard ratio 1.58, 95 % confidence interval 1.16–2.15; P = 0.004). Conclusions: Young age at onset is an independent negative prognostic factor in breast cancer. Further studies are required to develop new therapeutic strategies for YA breast cancer patients.

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalBreast Cancer Research and Treatment
Volume160
Issue number1
DOIs
Publication statusPublished - 2016 Nov 1

Keywords

  • Breast cancer
  • Multivariable analysis
  • Prognosis
  • Surveillance data
  • Young women

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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