@article{b84b84a8a03c470d9d69f1e06c78c76a,
title = "Ynamide Preactivation Allows a Regio- and Stereoselective Synthesis of α,β-Disubstituted Enamides",
abstract = "A novel ynamide preactivation strategy enables the use of otherwise incompatible reagents and allows preparation of α,β-disubstituted enamides with high regio- and stereoselectivity. Mechanistic analysis reveals the intermediacy of a triflate-bound intermediate as a solution-stable, effective keteniminium reservoir, whilst still allowing subsequent addition of organometallic reagents.",
keywords = "keteniminium, preactivation, regioselectivity, stereoselectivity, ynamides",
author = "Baldassari, {Lucas L.} and {de la Torre}, Aur{\'e}lien and Jing Li and L{\"u}dtke, {Diogo S.} and Nuno Maulide",
note = "Funding Information: We thank Dr. H. K{\"a}hlig (University of Vienna) and Prof. F. P. Santos (UFRGS) for expert assistance with NMR experiments. Generous support of this research by the EU (VINCAT CoG 682002 to N.M.), the DFG (MA 4861/4-2), the Brazilian agencies CAPES (CAPES-PVE PVE 88881.030400/2013-01), CNPq, and the University of Vienna is acknowledged. L.L.B. thanks CAPES for a Sandwich PhD fellowship. Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2017",
month = dec,
day = "4",
doi = "10.1002/anie.201709128",
language = "English",
volume = "56",
pages = "15723--15727",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "49",
}