YKT6 as a second SNARE protein of mammalian autophagosomes

Noboru Mizushima, Takahide Matsui, Hayashi Yamamoto

Research output: Contribution to journalComment/debatepeer-review

2 Citations (Scopus)

Abstract

Mammalian autophagosomes possess the Qa-SNARE STX17 (syntaxin 17) for fusion with lysosomes. However, STX17 is not absolutely required for fusion because STX17 knockout cells partially retain autophagosome-lysosome fusion activity. We recently identified YKT6, an R-SNARE, as another autophagosomal SNARE protein that acts independently of STX17 in mammals. Here, we discuss the features and functions of autophagosomal SNARE proteins by comparing STX17 and YKT6. Abbreviations: SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor; STX17, syntaxin 17.

Original languageEnglish
Pages (from-to)176-177
Number of pages2
JournalAutophagy
Volume15
Issue number1
DOIs
Publication statusPublished - 2019 Jan 2

Keywords

  • Autophagosome
  • SNARE
  • YKT6
  • lysosome
  • syntaxin 17

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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