Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet

Kazuyuki Hiwatashi, Yasuyuki Kosaka, Nao Suzuki, Keishi Hata, Toshiyuki Mukaiyama, Kenji Sakamoto, Hitoshi Shirakawa, Michio Komai

    Research output: Contribution to journalArticlepeer-review

    43 Citations (Scopus)

    Abstract

    The effects of dietary Yamabushitake mushroom (Hericium erinaceus) on lipid metabolism were examined. C57BL/6J mice were fed a high-fat diet containing hot-water extract (HW-E) and an ethanol extract (EtOH-E) of Yamabushitake mushroom. Administration of HW-E or EtOH-E with a high-fat diet for 28 d resulted in a significant decrease in body weight gain, fat weight, and serum and hepatic triacylglycerol levels. Our in vitro experiments indicated that EtOH-E acts as an agonist of peroxisome proliferator-activated receptor α (PPARα). Quantitative analyses of hepatic mRNA levels revealed that EtOH-E administration resulted in up-regulation of mRNA for a number of PPARα-regulating genes in spite of the fact that the gene expression of PPARα did not change. These results suggest that EtOH-E improves lipid metabolism in mice fed a high-fat diet, and that these effects were mediated by modulation of lipid metabolic gene expression, at least in part via activation of PPARα.

    Original languageEnglish
    Pages (from-to)1447-1451
    Number of pages5
    JournalBioscience, Biotechnology and Biochemistry
    Volume74
    Issue number7
    DOIs
    Publication statusPublished - 2010

    Keywords

    • Hericium erinaceus
    • Lipid metabolism
    • Peroxisome proliferator-activated receptor α(PPARα)
    • Yamabushitake mushroom

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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