Xylitol inhibition of anaerobic acid production by Streptococcus mutans at various pH levels

H. Miyasawa, Y. Iwami, H. Mayanagi, Nobuhiro Takahashi

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Xylitol inhibits the glycolysis and growth of Streptococcus mutans. We studied the inhibitory effect of xylitol on the acid production of S. mutans at several pH levels under the strictly anaerobic conditions found in the deep layer of dental plaque. Xylitol inhibited the rate of acid production from glucose and changed the profile of acidic end products to formate-acetate dominance, with a decrease in the intracellular level of fructose 1,6-bisphosphate and an intracellular accumulation of xylitol 5-phosphate (X5P). These results were notable at pH 5.5-7.0, but were not evident at pH 5.0. Since the activity of phosphoenolpyruvate phosphotransferase for xylitol was greater at higher pH, it is suggested that xylitol could be incorporated more efficiently at higher pH and that the resultant accumulation of X5P could inhibit the glycolysis of S. mutans more effectively.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalOral Microbiology and Immunology
Issue number4
Publication statusPublished - 2003 Aug


  • Anaerobic
  • Glycolysis
  • Streptococcus mutans
  • Xylitol
  • pH

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Dentistry(all)
  • Microbiology (medical)


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