Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity

Hippolyte K. Wabo, Haruhisa Kikuchi, Yasuhiro Katou, Pierre Tane, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3-b]xanthen-11(2H)-one or butyraxanthone E (1), along with the known compounds 30-epi-cambogin (2), 1,7-dihydroxyxanthone (3) and 1,5-dihydroxyxanthone (4) were isolated from the roots of Pentadesma butyracea. Their structures were elucidated by spectroscopic means and comparison with published data. Their antiproliferative activities were evaluated against Drosophila S2 cells and two human cancer cell lines, THP-1 (leukemia) and HCT116 (colon cancer). Compounds 1 and 2 showed moderate antiproliferative activity against Drosophila S2 cells and the HCT116 cell line, respectively. Compound 2 was active against Drosophila S2 cells.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalPhytochemistry Letters
Volume3
Issue number2
DOIs
Publication statusPublished - 2010 Jun 11

Keywords

  • Antiproliferative activity
  • Benzophenone
  • Butyraxanthone E
  • Guttiferae
  • Pentadesma butyracea
  • Xanthone

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

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