Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity

Hippolyte K. Wabo; Haruhisa Kikuchi; Yasuhiro Katou; Pierre Tane; Yoshiteru Oshima

doi:10.1016/j.phytol.2010.02.006

Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity

Hippolyte K. Wabo, Haruhisa Kikuchi, Yasuhiro Katou, Pierre Tane, Yoshiteru Oshima

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3-b]xanthen-11(2H)-one or butyraxanthone E (1), along with the known compounds 30-epi-cambogin (2), 1,7-dihydroxyxanthone (3) and 1,5-dihydroxyxanthone (4) were isolated from the roots of Pentadesma butyracea. Their structures were elucidated by spectroscopic means and comparison with published data. Their antiproliferative activities were evaluated against Drosophila S2 cells and two human cancer cell lines, THP-1 (leukemia) and HCT116 (colon cancer). Compounds 1 and 2 showed moderate antiproliferative activity against Drosophila S2 cells and the HCT116 cell line, respectively. Compound 2 was active against Drosophila S2 cells.

Original language	English
Pages (from-to)	104-107
Number of pages	4
Journal	Phytochemistry Letters
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.phytol.2010.02.006
Publication status	Published - 2010 Jun 11

Keywords

Antiproliferative activity
Benzophenone
Butyraxanthone E
Guttiferae
Pentadesma butyracea
Xanthone

ASJC Scopus subject areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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title = "Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity",

abstract = "A new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3-b]xanthen-11(2H)-one or butyraxanthone E (1), along with the known compounds 30-epi-cambogin (2), 1,7-dihydroxyxanthone (3) and 1,5-dihydroxyxanthone (4) were isolated from the roots of Pentadesma butyracea. Their structures were elucidated by spectroscopic means and comparison with published data. Their antiproliferative activities were evaluated against Drosophila S2 cells and two human cancer cell lines, THP-1 (leukemia) and HCT116 (colon cancer). Compounds 1 and 2 showed moderate antiproliferative activity against Drosophila S2 cells and the HCT116 cell line, respectively. Compound 2 was active against Drosophila S2 cells.",

keywords = "Antiproliferative activity, Benzophenone, Butyraxanthone E, Guttiferae, Pentadesma butyracea, Xanthone",

author = "Wabo, {Hippolyte K.} and Haruhisa Kikuchi and Yasuhiro Katou and Pierre Tane and Yoshiteru Oshima",

year = "2010",

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doi = "10.1016/j.phytol.2010.02.006",

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T1 - Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity

AU - Wabo, Hippolyte K.

AU - Kikuchi, Haruhisa

AU - Katou, Yasuhiro

AU - Tane, Pierre

AU - Oshima, Yoshiteru

PY - 2010/6/11

Y1 - 2010/6/11

N2 - A new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3-b]xanthen-11(2H)-one or butyraxanthone E (1), along with the known compounds 30-epi-cambogin (2), 1,7-dihydroxyxanthone (3) and 1,5-dihydroxyxanthone (4) were isolated from the roots of Pentadesma butyracea. Their structures were elucidated by spectroscopic means and comparison with published data. Their antiproliferative activities were evaluated against Drosophila S2 cells and two human cancer cell lines, THP-1 (leukemia) and HCT116 (colon cancer). Compounds 1 and 2 showed moderate antiproliferative activity against Drosophila S2 cells and the HCT116 cell line, respectively. Compound 2 was active against Drosophila S2 cells.

AB - A new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3-b]xanthen-11(2H)-one or butyraxanthone E (1), along with the known compounds 30-epi-cambogin (2), 1,7-dihydroxyxanthone (3) and 1,5-dihydroxyxanthone (4) were isolated from the roots of Pentadesma butyracea. Their structures were elucidated by spectroscopic means and comparison with published data. Their antiproliferative activities were evaluated against Drosophila S2 cells and two human cancer cell lines, THP-1 (leukemia) and HCT116 (colon cancer). Compounds 1 and 2 showed moderate antiproliferative activity against Drosophila S2 cells and the HCT116 cell line, respectively. Compound 2 was active against Drosophila S2 cells.

KW - Antiproliferative activity

KW - Benzophenone

KW - Butyraxanthone E

KW - Guttiferae

KW - Pentadesma butyracea

KW - Xanthone

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