X-ray imaging technique using colloid solution of Au/silica/poly(ethylene glycol) nanoparticles

Y. Kobayashi, H. Inose, R. Nagasu, T. Nakagawa, Y. Kubota, K. Gonda, N. Ohuchi

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

This work describes X-ray imaging of mouse using colloid solution of silica coated Au (Au/SiO2) nanoparticles surface modified with poly(ethylene glycol) (PEG) (Au/SiO2/PEG). A colloid solution of Au nanoparticles was prepared by reducing Au ions (III) with sodium citrate. Au/SiO2 nanoparticles were fabricated by a sol-gel method using tetraethylorthosilicate, water and sodium hydroxide in ethanol in the presence of Au nanoparticles surface modified with (3-aminopropyl)- trimethoxysilane. A computed tomography value of the Au/SiO2 colloid solution with an Au concentration of 0.083M was as high as 1421.2 Hounsfield units, which was higher than that of a commercial X-ray contrast agent with the same iodine concentration. Surface modification of the Au/SiO2 particles with PEG, or PEGylation of the particle surface, was performed using (3- aminopropyl)trimethoxysilane and PEG for the Au/SiO2 particles. Tissues of mouse could be imaged by injecting the colloid solutions of Au/SiO2 particles or Au/SiO2/PEG particles into it. The PEGylation provided an increase in residence time of particles in the mouse.

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalMaterials Research Innovations
Volume17
Issue number7
DOIs
Publication statusPublished - 2013 Nov

Keywords

  • Au
  • Core shell
  • Nanoparticle
  • Poly(ethylene glycol)
  • Silica
  • X-ray contrast agent

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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