Writing's shadow: Corticospinal activation during letter observation

Masahiro Nakatsuka, Mohamed Nasreldin Thabit, Satoko Koganemaru, Ippei Nojima, Hidenao Fukuyama, Tatsuya Mima

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We can recognize handwritten letters despite the variability among writers. One possible strategy is exploiting the motormemory of orthography. By using TMS, we clarified the excitatory and inhibitory neural circuits of the motor corticospinal pathway that might be activated during the observation of handwritten letters. During experiments, participants looked at the handwritten or printed single letter that appeared in a random order. The excitability of the left and right primary motor cortex (M1) was evaluated by motor-evoked potentials elicited by single-pulse TMS. Short interval intracortical inhibition (SICI) of the left M1 was evaluated using paired-pulse TMS. F waves were measured for the right ulnar nerve. We found significant reduction of corticospinal excitability only for the right hand at 300-400msec after each letter presentation without significant changes in SICI. This suppression is likely to be of supraspinal origin, because of no significant alteration in F-wave amplitudes. These findings suggest that the recognition of handwritten letters may include the implicit knowledge of "writing" in M1. The M1 activation associated with that process, which has been shown in previous neuroimaging studies, is likely to reflect the active suppression of the corticospinal excitability.

Original languageEnglish
Pages (from-to)1138-1148
Number of pages11
JournalJournal of Cognitive Neuroscience
Volume24
Issue number5
DOIs
Publication statusPublished - 2012 May
Externally publishedYes

ASJC Scopus subject areas

  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'Writing's shadow: Corticospinal activation during letter observation'. Together they form a unique fingerprint.

Cite this