Wound healing effect of malotilate in rats

Yoshimi Niwano, Hiroyasu Koga, Atsushi Sakai, Kazuo Kanai, Hiroshi Hamaguchi, Matazaemon Uchida, Tetsuhiko Tachikawa

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The wound healing effect of malotilate (CAS 59937-28-9, NKK-105) was investigated by using an excisional skin-wound model produced on the back of normal and healing-impaired (induced by prednisolone pretreatment) rats. The rapid decrease in the square measure of wound areas and the improvement in the histological evaluation clarified that 0.3% and 1% cream preparations of malotilate were obviously effective in accelerating spontaneous healing in the normal rats. The accelerative effect of malotilate cream preparations was likely superior to that of an ointment containing 5% deproteinized calf blood extract used as a reference agent. The same effect was also observed in the healing-impaired rats. The histological findings revealed that a thicker and more cellular granulation tissue, which in turn created an adequate bed for rapid re-epithelization, was formed in the malotilate-treated animals. Acceleration of granulation tissue formation by malotilate was also supported by the cotton pellet implantation method. It is concluded from these results that malotilate seems to be a promising agent for topical wound therapy.

Original languageEnglish
Pages (from-to)450-455
Number of pages6
JournalArzneimittel-Forschung/Drug Research
Issue number4
Publication statusPublished - 1996 May 6


  • CAS 59937-28-9
  • NKK-105, wound healing effect
  • malotilate

ASJC Scopus subject areas

  • Drug Discovery


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