WoLF PSORT: Protein localization predictor

Paul Horton, Keun Joon Park, Takeshi Obayashi, Naoya Fujita, Hajime Harada, C. J. Adams-Collier, Kenta Nakai

Research output: Contribution to journalArticlepeer-review

1771 Citations (Scopus)

Abstract

WoLF PSORT is an extension of the PSORT II program for protein subcellular location prediction. WoLF PSORT converts protein amino acid sequences into numerical localization features; based on sorting signals, amino acid composition and functional motifs such as DNA-binding motifs. After conversion, a simple k-nearest neighbor classifier is used for prediction. Using html, the evidence for each prediction is shown in two ways: (i) a list of proteins of known localization with the most similar localization features to the query, and (ii) tables with detailed information about individual localization features. For convenience, sequence alignments of the query to similar proteins and links to UniProt and Gene Ontology are provided. Taken together, this information allows a user to understand the evidence (or lack thereof) behind the predictions made for particular proteins. WoLF PSORT is available at wolfpsort.org.

Original languageEnglish
Pages (from-to)W585-W587
JournalNucleic acids research
Volume35
Issue numberSUPPL.2
DOIs
Publication statusPublished - 2007 Jul

ASJC Scopus subject areas

  • Genetics

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