Whole brain and grey matter volume of Japanese patients with multiple sclerosis

Tetsuya Akaishi, Ichiro Nakashima, Shunji Mugikura, Masashi Aoki, Kazuo Fujihara

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey matter. Patients with progressive MS showed severer atrophy. We show the existence of pathological brain atrophy in Japanese MS patients for the first time, although the rate of atrophy may be much slower than in Caucasian patients.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalJournal of Neuroimmunology
Publication statusPublished - 2017 May 15


  • Brain atrophy
  • Grey matter volume
  • Japanese
  • Multiple sclerosis
  • Whole brain volume

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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