What's New in the Localization of Sex Steroids in the Human Ovary and its Tumors?

H. Sasano, N. Sasano

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

It is important to understand the distribution of steroidogenesis in steroid producing tissues in order to obtain a better understanding of steroid metabolism. Recent advances in purification and subsequent generation of antibodies against cytochromes P-450 specificif or steroid hormone biosynthesis have made it possible to localize the sites of steroidogenesis immunohistochemically. This review provides the localization of sex-steroid hormone biosynthesis in normal and pathological human ovaries including sex-cord stromal tumors, hyperthecosis and Brenner tumor, as determined by the tissue distribution of immunoreactivity ofindividual enzymes specific for different stages of the biosynthetic process.

Original languageEnglish
Pages (from-to)942-948
Number of pages7
JournalPathology Research and Practice
Volume185
Issue number6
DOIs
Publication statusPublished - 1989 Jan 1

Keywords

  • Cytochrome P-450
  • Ovarian neoplasms
  • Ovary
  • Sex-cord tumors
  • Steroidogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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