What is the mechanism of the calcium influx to pancreatic acinar cells evoked by secretagogues?

O. H. Petersen, Y. Maruyama

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The simple model shown in Fig. 1 can be used to explain pancreatic acinar stimulus-secretion coupling by assuming that the Ca-activated cation channel is not perfectly selective for mono-valent cations, but enables a very slight leak of divalent cations. Stimulation by ACh or CCK releases intracellular Ca (probably from the plasma membrane) raising [Ca++]i. This opens up the 30-35 pS channels giving rise to Na influx and depolarization. At the same time Ca can leak into the cells through the same channels, maintaining an elevated [Ca++]i. Removal of agonist (and/or inclusion of antagonist) causes a rapid reuptake of Ca into the trigger pool (Stolze and Schulz 1980) causing a decrease in [Ca++]i and closure of the channel with rapid return to the resting potential and the resting [Ca++]i.

Original languageEnglish
Pages (from-to)82-84
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume396
Issue number1
DOIs
Publication statusPublished - 1983 Jan 1

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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