Wharton-fragmentation-based approach to the carbocyclic core of the phomoidrides

Graham K. Murphy, Naoto Hama, Aaron Bedermann, Ping Dong, Chris M. Schneider, Travis C. McMahon, Ran N. Tao, Barry M. Twenter, David A. Spiegel, John L. Wood

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The carbocyclic core of the phomoidrides has been synthesized efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels-Alder sequence, tandem radical cyclization, and a late-stage Wharton fragmentation of a densely functionalized isotwistane skeleton.

Original languageEnglish
Pages (from-to)4544-4547
Number of pages4
JournalOrganic letters
Issue number17
Publication statusPublished - 2012 Sep 7

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Wharton-fragmentation-based approach to the carbocyclic core of the phomoidrides'. Together they form a unique fingerprint.

Cite this