Weak activity of udp-glucuronosyltransferase toward bisphenol analogs in mouse perinatal development

Risa Yabusaki, Hidetomo Iwano, Sumito Tsushima, Nanako Koike, Naoko Ohtani, Kentaro Tanemura, Hiroki Inoue, Hiroshi Yokota

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Bisphenol A (BPA) is a widely used industrial chemical that disrupts endocrine function. BPA is an endocrine disrupting chemical (EDC) that has been demonstrated to affect reproductive organ development, brain development, metabolic disease and post-natal behavior. Accordingly, Bisphenol analogs, Bisphenol F (BPF, bis (4-hydroxyphenyl) methane) and Bisphenol AF (BPAF, 4,4-hexafluoroisopropylidene) diphenol) are used as replacements for BPA. BPA is mainly metabolized by UDP-glucuronosyltransferase (UGT), UGT2B1, but this effective metabolizing system is weak in the fetus. In the present study, we demonstrated that hepatic UGT activity toward BPAF was very weak, in comparison with BPA and BPF, in the fetus, pups and dams. Conversely, hepatic UGT activity toward BPF was very weak in the fetus and newborn pups, and was increased to the same level as BPA post-partum. In conclusion, BPAF possibly tends to accumulate in the fetus, because of weak metabolism during the perinatal period, suggesting that the metabolism of individual Bisphenol analogs requires assessment to properly gauge their risks.

Original languageEnglish
Pages (from-to)1479-1484
Number of pages6
JournalJournal of Veterinary Medical Science
Volume77
Issue number11
DOIs
Publication statusPublished - 2015 Dec 1

Keywords

  • Bisphenol A
  • Bisphenol AF
  • Bisphenol F
  • UDP glucuronosyl transferase (UGT)

ASJC Scopus subject areas

  • veterinary(all)

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