Wavelet-based resolution recovery using anatomical prior provides quantitative recovery for human population phantom PET [11C] raclopride data

Miho Shidahara, Charalampos Tsoumpas, Colm McGinnity, Takashi Kato, Hajime Tamura, Alexander Hammers, Hiroshi Watabe, Federico E. Turkheimer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this study was the evaluation of a wavelet-based resolution recovery (RR) method, named structural and functional synergy for RR (SFS-RR), for a variety of simulated human brain [11C]raclopride PET images. Simulated datasets of 15 human phantoms were processed by SFS-RR using an anatomical prior. This anatomical information was in the form of a hybrid segmented-atlas, which combines an MRI for anatomical labelling and a PET image for functional labelling of each anatomical structure. First, the relationship between the FWHM of the original the PET image and its resolution recovered version was investigated. Then quantitative evaluation was performed by comparing caudate, putamen and cerebellum regions of the true image; simulated PET image; and RR image. The spatial resolution of the original PET image effected on how accurately SFS-RR recovers the image counts in striatum regions. The resolution in striatum, and cerebellum regions was successfully recovered for all the 15 human phantoms. The proposed methodology proved effective in the resolution recovery of small structures of brain [11C]raclopride PET images. The improvement was consistent across the anatomical variability of a simulated population, provided accurate anatomical segmentations are available.

Original languageEnglish
Title of host publication2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3097-3101
Number of pages5
ISBN (Print)9781467301183
DOIs
Publication statusPublished - 2011
Event2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 - Valencia, Spain
Duration: 2011 Oct 232011 Oct 29

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
CountrySpain
CityValencia
Period11/10/2311/10/29

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Shidahara, M., Tsoumpas, C., McGinnity, C., Kato, T., Tamura, H., Hammers, A., Watabe, H., & Turkheimer, F. E. (2011). Wavelet-based resolution recovery using anatomical prior provides quantitative recovery for human population phantom PET [11C] raclopride data. In 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 (pp. 3097-3101). [6152561] (IEEE Nuclear Science Symposium Conference Record). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2011.6152561