Wave propagation of junctional remodeling in collective cell movement of epithelial tissue: Numerical simulation study

Tetsuya Hiraiwa, Erina Kuranaga, Tatsuo Shibata

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    During animal development, epithelial cells forming a monolayer sheet move collectively to achieve the morphogenesis of epithelial tissues. One driving mechanism of such collective cell movement is junctional remodeling, which is found in the process of clockwise rotation of Drosophila male terminalia during metamorphosis. However, it still remains unknown how the motions of cells are spatiotemporally organized for collective movement by this mechanism. Since these moving cells undergo elastic deformations, the influence of junctional remodeling may mechanically propagate among them, leading to spatiotemporal pattern formations. Here, using a numerical cellular vertex model, we found that the junctional remodeling in collective cell movement exhibits spatiotemporal self-organization without requiring spatial patterns of molecular signaling activity. The junctional remodeling propagates as a wave in a specific direction with a much faster speed than that of cell movement. Such propagation occurs in both the absence and presence of fluctuations in the contraction of cell boundaries.

    Original languageEnglish
    Article number66
    JournalFrontiers in Cell and Developmental Biology
    Volume5
    Issue numberJUL
    DOIs
    Publication statusPublished - 2017 Jul 19

    Keywords

    • Cell intercalation
    • Collective cell migration
    • Epithelial cells
    • Mathematical model
    • Mechanobiology
    • Vertex model

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

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