Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation

Masaki Kikugawa, Hiroyasu Tsutsuki, Tomoaki Ida, Hidemitsu Nakajima, Hideshi Ihara, Tatsuji Sakamoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Ferulic acid (FA) has been reported to exhibit protective effects against amyloid-β (Aβ)-induced neurodegeneration in vitro and in vivo. Recently, we developed two water-soluble FA derivatives: 1-feruloyl glycerol and 1-feruloyl diglycerol. In this study, we examined the neuroprotective effects of these water-soluble FA derivatives on Aβ-induced neurodegeneration both in vitro and in vivo. FA and water-soluble FA derivatives inhibited Aβ aggregation and destabilized pre-aggregated Aβ to a similar extent. Furthermore, water-soluble FA derivatives, as well as FA, inhibited Aβ-induced neuronal cell death in cultured neuronal cells. In in vivo experiments, oral administration of water-soluble FA derivatives to mice improved Aβ-induced dysmnesia assessed by contextual fear conditioning test and protected hippocampal neurons against Aβ-induced neurotoxicity. This study provides useful evidence suggesting that water-soluble FA derivatives are expected to be effective neuroprotective agents.

Original languageEnglish
Pages (from-to)547-553A
JournalBioscience, Biotechnology and Biochemistry
Volume80
Issue number3
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • Ferulic acid
  • Neuroprotective agent

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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