W-shape nucleic acid (WNA) for selective formation of non-natural anti-parallel triplex including a TA interrupting site

Shigeki Sasaki, Hiroyuki Yamauchi, Fumi Nagatsugi, Ryo Takahashi, Yosuke Taniguchi, Minoru Maeda

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Novel nucleoside analogs have been designed for selective formation of anti-parallel triplexes including a TA or a CG interrupting site. The new compounds are constructed of a W-shape bicyclic nucleic acid (WNA) bearing an aromatic ring as a stacking motif and a guanine for the formation of Hoogesteen hydrogen bonds, and are expected to effect triplex stabilization by both stacking and complementary hydrogen bonds. Purine-rich triplex-forming oligodeoxynucleotide (TFO) incorporating the new analog, WNA-7βG, formed a stable triplex with high selectivity to the TA site.

Original languageEnglish
Pages (from-to)6915-6918
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number39
DOIs
Publication statusPublished - 2001 Sep 24
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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