Abstract
Immunohistochemistry for VR1, a nociceptive transducer for vanilloid compounds, protons and heat (>43°C), was performed on the rat trigeminal ganglion (TG). The immunoreactivity (IR) was detected in 20% of TG cells and these neurons were mostly small- to medium-sized (mean±S.D. 427±189 μm2). Twenty-six percent of the TG neurons retrogradely labeled from the facial skin exhibited VR1-IR, while the IR was detected in only 8% of those labeled from the tooth pulp. Co-expression of VR1 was common among the calcitonin gene-related peptide-immunoreactive cutaneous neurons (63%) but not among the similar tooth pulp neurons (20%). The present study indicates that primary nociceptive neurons which respond to vanilloid compounds, protons and heat are abundant in the facial skin but not in the tooth pulp.
Original language | English |
---|---|
Pages (from-to) | 184-188 |
Number of pages | 5 |
Journal | Brain research |
Volume | 890 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2001 Jan 26 |
Externally published | Yes |
Keywords
- Calcitonin gene-related peptide
- Immunohistochemistry
- Skin
- Tooth pulp
- Trigeminal ganglion
- VR1
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology