Voxelwise multivariate statistics and brain-wide machine learning using the full diffusion tensor

Anne Laure Fouque, Pierre Fillard, Anne Bargiacchi, Arnaud Cachia, Monica Zilbovicius, Benjamin Thyreau, Edith Le Floch, Philippe Ciuciu, Edouard Duchesnay

Research output: Contribution to journalConference articlepeer-review

3 Citations (Scopus)


In this paper, we propose to use the full diffusion tensor to perform brain-wide score prediction on diffusion tensor imaging (DTI) using the log-Euclidean framework., rather than the commonly used fractional anisotropy (FA). Indeed, scalar values such as the FA do not capture all the information contained in the diffusion tensor. Additionally, full tensor information is included in every step of the pre-processing pipeline: registration, smoothing and feature selection using voxelwise multivariate regression analysis. This approach was tested on data obtained from 30 children and adolescents with autism spectrum disorder and showed some improvement over the FA-only analysis.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6892 LNCS
Issue numberPART 2
Publication statusPublished - 2011
Externally publishedYes
Event14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011 - Toronto, ON, Canada
Duration: 2011 Sep 182011 Sep 22

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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